Pecsi Tudomanyegyetem

Vichem Chemie Kutató Kft.

Szolcsányi, János

Orfi, László

Szüts, Tamás

Wáczek, Frigyes

Kéri, György

Németh, József

Pintér, Erika

Helyes, Zsuzsanna

Frigyes Wáczek

György Kéri

László Örfi

Péter Bánhegyi

Zsuzsanna Helyes

Erika Pintér

Tamás Szüts

Lászlö Örfi

Zsolt Szekélyhidi

János Szolcsányi

Éva Szöke

László Orfi

József Németh

The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.

Agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders

The invention relates to novel tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, as well as their pharmaceutically acceptable salts. The subject of the invention too the process for producing the compounds and their use as a pharmaceutically active agent and as pharmaceutical compositions for prophylaxis and/or treatment of proliferative diseases such as cancer.

Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use

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Budapest, Hungary

Frigyes Wáczek