Egis Gyogyszergyar

Basf Aktiengesellschaft

Egyt Gyogyszervegyeszeti Gyar

Egis Cyogyszergvar

Egis Gyogyszergyat

Frigyes Gorgenyi

Marton Fekete

Gabor Gigler

Lujza E Petocz

Attila Mandi

Istvan Simonyi

Jozsef Reiter

Istvan Gyertyan

Istvan Gacsalyi

Peter Tompe

Ivan Beck

Jozsef Barkoczy

Eniko Szirt Nee Kiszelly

Laszlo Pongo

Margit Csorgo

Eva J Tajthy Nee Juhasz

Pal Benko

Gyula Sebestyen

Kalman Nagy

Daniel Bozsing

Pal Vago

Laszlo Levai

Andras Dietz

Eva Furdyga

Janos Imre

Marta Kovacs

Elemer Jakfalvi

Gyorgyi Kovanyi Nee Lax

Jozsef Kenderfi

Istvan Seres

Gyorgy Mikite

Maria Szeli

Gyorgyi Zalavari Nee Dosa

Eva Poczik

Ilona Dinnyes Nee Nagy

Erzsebet Kiss Nee Bertok

Pal Fekete

Klara Reiter Nee Esses

Janos Egri

Maria Szecsey Nee Hegedus

Gizella Zsila

Eniko Kiszelly

Erzsebet Barczay

Katalin Zukovics Nee Sumeg

Janos Brlik

Eva Szabo

Peter Slegel

Klara Gado

Maria Kiraly Nee Ignacz

Gyula Deak

Margit Doda

Lajos Gyorgy

Ilona Sztruhar

Enik Szirt Nee Kiszelly

Bela Kanyicska

Margit Nagy

Maria Krisztian

Gizella Miholics

Antal Mosonyi

Maria Hegedus

Sandor Erdos

Lidia Fedina

Egri Janos

Erzsebet Zara Nee Kaczian

Andras Seregi

Erzsebet Toth Nee Pecsi

Maria Horvath Nee Gaal

Gyorgyi Vaszovics Nee Reichmann

Sandor Manyai

Katalin Sumeg Nee Zukovics

Gizelle Miholics

Dezso Danyi

Szvetlana Zsarnoczai Nee Kurnyecova

Sarolta Benko Nee Markus

Magdolna Kenyeres Nee Feher

Agnes Halbauer Nee Nagy

Margit Csorg

Ludmila Rohacs Nee Zamkovaja

Maria Szecsey Nee Heged S

Gabor Berecz

Lujza Pet Cz

Josef Barkoczy

Josef Reiter

Zoltan Torma

Aranka Hegedus Nee Szima

Sandor Vajas

The disclosed compounds have the formula ##STR1## wherein Q is a 6-membered saturated heterocyclic group or a group S(O)pR.sup.3, wherein

5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

The invention relates to novel triazolyl thioamides of the general formula (I), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s), or a group of the formula SR.sup.1, wherein

Triazolyl thioamide derivates

This invention relates to novel triazolyl hydrazide derivatives and a process for the preparation thereof. The new triazolyl hydrazide derivatives of the general formula (I). ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally substituted by a C.sub.1-4 alkyl group; or a group of general formula SR.sup.1, wherein

Triazolyl hydrazide derivatives

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

This invention relates to novel triazolo derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said triazolo derivatives for the treatment of diseases and also for the preparation of pharmaceutical compositions suitable for the treatment of the said diseases. The new triazolo derivatives of the general formulae (Ia) and (Ib), ##STR1## wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C.sub.1-4 alkyl substituent(s); or a group of the formula SR.sup.1, wherein

Triazolo derivatives and process for their preparation

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyridin e (referred to further on as 'nifedipine') as active ingredient which comprises admixing a solution or solutions of 1 part by weight of nifedipine, 0.1-1.5 parts by weight of one or more hydrophilizing agent(s) and 0.05-1.5 parts by weight of one or more retarding agent(s) formed with one or more identical or different solvent(s) completely or partly and applying the solution(s) thus obtained simultaneously or in succession onto an inert carrier, drying and sieving the product thus obtained and subsequently admixing the same with suitable conventional auxiliary agents and compressing the mixture thus obtained to tablets in a known manner and coating the tablets or filling the mixture into capsules.

Solid pharmaceutical composition and a process for preparing same

The present invention relates to an aerosol composition free of propellant gas, comprising nitroglycerin as active ingredient. The composition according to the invention is composed of:

Aerosol composition comprising nitroglycerin as active ingredient

The compounds of the general Formula I ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each stands for hydrogen, hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy-C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or phenyl-(C.sub.1-3 alkoxy), or R.sup.1 and R.sup.2 together form C.sub.1-2 alkylenedioxy; with the proviso that at least one of symbols R.sup.1 and R.sup.2 is other than hydrogen and with the further proviso that R.sup.1 and R.sup.2 can not represent 3,4-dimethoxy substitution) and their pharmaceutically acceptable acid addition salts exhibit useful analgesic, antipyretic, anti-inflammatory, anti-anginal and antioxidant effect.

Pharmaceutical compositions

The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.

Pharmaceutical composition

The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.

Pharmaceutical composition comprising an organic zinc complex and a

The invention relates to new 4-aryl-2-methyl-1,2,3,4-tetrahydro-isoquinoline derivatives of the general Formula I ##STR1## and salts thereof wherein

Isoquinoline derivatives

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Budapest, Hungary

Frigyes Gorgenyi