B. Braun Melsungen Ag

Intermedicat Gmbh

Friedrich Von Der Haar

Karl-Siegfried Boos

Robert Mardorf

Dietrich Siedel

For the quantitative selective removal or/and preparative isolation of tumour necrosis factor (TNF) or/and lipopolysaccharides from aqueous liquids, in particular blood, plasma or serum, the aqueous liquid is passed over an adsorption material which consists of a porous supporting material to which functional groups made of synthetic or/and semisynthetic or/and natural polyanion chains and namely in a linear or branched form, are covalently bound and if desired, the molecules chromatographically separated in this way are eluted from the adsorption material using a saline solution. A device according to the present invention for the extracorporeal removal of tumour necrosis factor and/or lipopolysaccharides (LPS) from aqueous liquids, in particular blood, plasma or serum, consists of a cylindrical housing which is filled with an adsorption material which consists of a porous supporting material to which functional groups made of synthetic or/and semisynthetic or/and natural polyanion chains and namely in a linear or branched form, are covalently bound and is provided with covers at its front ends which each have a central inlet and outlet.

Process for the quantitative selective removal or preparative isolation

A syringe for an injector utilizes a cylinder having a deformable wall portion in the outlet end. Excessive pressure within the syringe cylinder, or contact with the syringe piston at the end of its stroke distends the deformable wall portion of the cylinder, actuating a sensor which provides a signal.

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Melsungen, Germany

Friedrich Von Der Haar