Other

Regeneron Pharmaceuticals, Inc.

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Dyax Corporation

Friedrich Lottspeich

Hans Thoenen

George D Yancopoulos

Joachim Leibrock

Yves-Alain Barde

Victor Brantl

Agnes Henschen

Hansjorg Teschemacher

David Edgar

Nikos Panayotatos

Mark E Furth

Vivien Wong

Nancy Y Ip

Ronald M Lindsay

Thomas Manz

Piotr J Masiakowski

Ehrenfried Mehl

Adam Otasek

Craig Young

Andreas D&uuml;sterh&ouml;ft

Dan B Lindholm

Georg W Kreutzberg

Michael Sendtner

Kurt Stockli-Rippstein

Yoshihiro Arakawa

Patrick Desmond Carroll

Rudolf Georg Gotz

Ralph Alderson

Hans F Thoenen

Carolyn Hyman

Magdalena Hofer

Dan Lindholm

Francisco Zafra

DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby

Described are novel methods for producing microporous elements and microporous elements obtainable by such methods. Provided are also microporous elements including solid microparticles, which preferably modify the adsorptive properties of the microporous element. Described are also microporous elements which are linked to a support and/or a retainer as well as methods for their production. Filter elements comprising the above-described microporous elements are also provided. Furthermore, kits, diagnostic and pharmaceutical compositions comprising the aforementioned microporous or filter elements are described. Furthermore, uses of the aforementioned microporous and filter elements in microfiltration, chromatography, adsorption/immobilization of organic and inorganic compounds as well as for the preparation and/or detection of such compounds are disclosed.

Method for producing microporous elements, the microporous elements thus produced and uses thereof

The present invention relates to nucleic acid molecules encoding hypusines mutants having the biological activity of an inhibitor of cellular proliferation. The present invention further relates to vectors comprising said nucleic acid molecules, to hosts transformed with said vectors, to methods of producing the polypeptide encoded by the nucleic acid molecule of the invention as well as to the polypeptide itself. In addition, the present invention relates to pharmaceutical and diagnostic compositions comprising one or more of the aforementioned compounds, the methods for synchronizing cell growth and to the use of the vector of the invention in gene therapy.

Inhibitor of cellular proliferation

The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.

Method for producing biologically active human brain derived

The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.

Brain derived neurotrophic factor

The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the ability to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying an disolating additional members of this gene family.

Brain-derived neurotrophic factor

Pharmacologically active peptides

Peptides of the formula Tyr.sup.1 -X-A-Pro-B-Pro-C-Pro-D, in which Tyr.sup.1 is equal to the amino acid tyrosine and Pro is equal to the amino acid proline; A, B, C, D is any desired amino acid in the L-form and X any amino acid in the D-form, except D-proline, D-alanine, D-threonine and D-valine, preferably D-serine, D-arginine or D-methionine; they act opiate-like and may be used as medicaments and animal medicaments.

Pharmacologically active peptides and medicaments containing the same

Growing community of inventors

Neuried, Germany

Friedrich Lottspeich