Roche Diagnostics Operations, Inc.

Roche Operations Ltd.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Friedrich Karl Ackermann

Manfred Augstein

Andreas Calatzis

Blaine Edward Ramey

Rik Harbers

Robert Paul Sabo

Jean-Pierre Bolliger

Roland Hutter

Wolfgang Fabian

Phillip Edgar Pash

Patrick Sascha Labud

Guido Abel

Theresa Kitcoff

Matthew Carlyle Sauers

Michael Schabbach

Timothy L Beck

Udo Manser

Robert Lawrence Meek

Frederick Leland Wittekind, Iii

Joerg Schreiber

Markus Stephan Fuerst

Seth Faulkner Williams

Wolfgang Walter

Philip Edgar Pash

Seeth Faulkner Williams

Frederick Leland Iii Wittekind

A reagent management system is disclosed comprising a reagent container section for receiving reagent containers and a reagent reconstitution device for reconstituting dry, or lyophilized, reagents or concentrated reagents in reagent containers in order to carry out in-vitro diagnostic tests with the reconstituted reagents. A controller is programmed to instruct the reagent reconstitution device to automatically reconstitute an initial volume of a selected reagent type in reagent containers. The initial volume is calculated based on an open container stability time (OCS) of the reconstituted reagent type for each reagent container and on a number of tests to be carried out within the OCS of the reconstituted reagent type. A reagent container for use by the reagent management system and methods of automatically reconstituting a dry, or lyophilized reagent, or a concentrated liquid reagent in a reagent container to carry out an in-vitro diagnostic test with the reagent are disclosed.

Reagent management system

The present invention concerns diagnostic methods for coagulation testing involving determining anticoagulant activity elicited by a first anticoagulant in a sample comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.

Methods for universal determination of anticoagulant activity

Apparatuses and methods thereof to administer and manage a base unit for a handheld medical device are disclosed. In one embodiment, a base unit of the invention is in communication with a handheld medical device. The base unit is configured to provide an electrical connection to a power source to charge a battery of the handheld medical device. The base unit is also configured to perform an update to the operation of the base unit, wherein the update is initiated by the base unit upon receiving from the handheld medical device a data stream with information indicating that an update is contained in the data stream.

Apparatus and method to administer and manage an intelligent base unit for a handheld medical device

Apparatuses and methods providing data such as, for example, calibration and reagent information () over a network () to a measurement apparatus () which makes use of a consumable reagent () in a measuring process are disclosed. The present invention permits a measurement apparatus () to download the necessary code assignment () and calibration data () of the consumable reagent () by means of an electronic communication protocol from a host (). The host () can be a software application running on a host computer (), another measurement apparatus () with or without a code-key slot used to read a memory device providing the above mentioned information (), a dedicated connectivity device, such as a docking station (), a portable memory reader (), a remote computer (), and combinations thereof.

Host apparatus and method providing calibration and reagent information to a measurement apparatus which makes use of a consumable reagent in a measuring process

The invention relates to the field of modular analytical systems. The invention enables the topology of a modular analytical system to be determined without requiring additional complicated measures such as a system reset. The method/system is also adapted to industry standards such that CAN-busses can be used.

Method and system for determining the topology of a modular analysis system

The invention concerns an analytical system in which at least two modules are in contact with one another by a connecting plug, and a connecting plug which is suitable for connecting modules. When two modules are connected by the connecting plug a part of the plug extends partially underneath the bottoms of the modules such that the plug connection is secured by the dead weight of the modules.

Modular analytical system having at least two modules connected by a connecting plug

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Heidelberg, Germany

Friedrich Karl Ackermann