Hoechst Aktiengesellschaft

Hoechstaktiengesellschaft

Friedrich-Johannes Kammerer

Rudolf Schleyerbach

Robert R Bartlett

Ulrich Gebert

Werner Thorwart

Hans G Alpermann

Rudolph Schleyerbach

The present invention relates to 2-cyano-3-mercaptocrotonamide derivatives, a process for their preparation, and their use the treatment of immune disorders, carcinomatous disorders, rejection reactions in transplantations and skin disorders or allergy.

2-Cyano-3-mercaptocrotonamides

A pharmaceutical composition for use in the treatment of chronic Graft-versus-host diseases as well as autoimmune diseases, in particular for the treatment of systemic lupus erythematosus containing as an active ingredient at least one compound of the formula 1 or 2 ##STR1## the latter being present per se or in the form of a physiologically tolerable salt. The invention also relates to a dosage unit form of said pharmaceutical composition and a method of treating chronic Graft-versus host diseases as well as autoimmune diseases, in particular systemic lupus erythematosus.

Medicaments to combat autoimmune diseases

Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use Isoxazole-4-carboxamide derivatives and hydroxyalkylidene-cyanoacetamide derivatives are suitable for the treatment of carcinoses. These compounds can be prepared by known processes. Some of the compounds are novel and are additionally suitable for the treatment of rheumatic disorders.

Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides,

A pharmaceutical composition for use in the treatment of chronic Graft-versus-host diseases as well as autoimmune diseases, in particular for the treatment of systemic lupus erythematosus containing as an active ingredient at least one compound of the formulae 1 or 2 ##STR1## the latter being present per se or in the form of a physiologically tolerable salt. The invention also relates to a dosage unit form of said pharmaceutical composition and a method of treating chronic Graft-versus host diseases as well as autoimmune diseases, in particular systemic lupus erythematosus.

Medicament to combat autoimmune diseases

A pharmaceutical composition for use in the treatment of chronic Graft-versus-host diseases as well as autoimmune diseases, in particular for the treatment of systemic lupus erythematosus containing as an active ingredient at least one compound of the formulae 1 or 2 ##STR1## the latter being present per se or in the form of a physiologically tolerable salt. The invention also relates to a dosage unit form of said pharmaceutical composition and a method of treating chronic Graft-versus-host diseases as well as autoimmune diseases, in particular systemic lupus erythematosus.

Medicaments to combat autoimmune diseases, in particular systemic lupus

Medicaments to combat chronic graft-versus-host diseases

4-Isoxazolecarboxylic acid amides of the general formula I ##STR1## in which R denotes hydrogen, alkyl with up to 4 carbon atoms or halogenoalkyl with up to 2 carbon atoms and

Isoxazole derivatives and medicaments containing these compounds

5-Methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and a process for its preparation is described. The compound has an antirheumatic, antiphlogistic, antipyretic and analgesic action, and can be used for the treatment of multiple sclerosis.

Pharmaceutical preparation and method of treatment

5-Methylisoxazole-4-carboxylic-(4-trifluoromethyl)-anilide

Pyrano-heterocycles of the formula ##STR1## in which R.sup.1 represent hydrogen or an alkyl radical containing up to 4 carbon atoms; R.sup.2 represents hydrogen or an alkyl, alkoxy or haloalkyl radical each having up to 3 carbon atoms, or halogen; or R.sup.1 and R.sup.2 together form an ethylene or propylene group, and R.sup.3 and R.sup.4, independently of each other, are hydrogen or alkyl or alkoxy radicals each of which groups containing up to 3 carbon atoms, which may be unsubstituted or substituted totally or partially with halogen atoms, halogen or alkoxycarbonyl having up to 3 carbon atoms in the alkyl group and R.sup.5 represents a nitro group or hydrogen, their physiologically tolerated salts, processes for preparing these compounds and medicaments containing these compounds.

Growing community of inventors

Hochheim am Main, Germany

Friedrich-Johannes Kammerer