Other

Boehringer Mannheim Gmbh

Deutsches Krebsforschungszentrum

Friedrich Grummt

Ulrich Weidle

Ingrid Grummt

Martha M&uuml;ller

Birgitta Sauer

The present invention provides a drug delivery device comprising encapsulated cells that contain multiple copies of an expression cassette. The drug delivery device of the present invention is useful to supply an animal, including a human, with a therapeutically desirable molecule, including physiological activities lacking in disease conditions or antagonist against conditions in an animal, especially a human.

Encapsulated cells containing an amplified expression vector as a drug delivery device

The present invention relates to an expression vector having a foreign DNA. Said DNA at its 3&prime; end has a sequence which prevents the replication of the expression vector from occurring in the opposite direction to the transcription thereof. The invention also relates to a preparation containing such an expression vector and to the use of both in the permanent expression of foreign DNA in cells.

Expression vector for the permanent expression of foreign DNA

The present invention provides a vector for the expression of heterologous proteins in mammalian cells, wherein it contains at least one first consensus sequence is homologous to the ##STR1## in at least 10 nucleotides in total and including the first three thereof and at least one second sequence which in one of the 6th, 8th, 9th and 10th nucleotide, as well as in at least 9 nucleotides, is homologous to the sequence ##STR2## or in at least 10 nucleotides is homologous to the sequence

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Würzburg, Germany

Friedrich Grummt