Leland Stanford Junior University

Friedrich Engelke

Richard Neil Zare

Joel R Kimmel

Jong H Hahn

Bradbury-Nielson gates for the modulation of beams of charged particles, particularly ion beams in mass spectrometry, have been produced with an adjustable wire spacing down to 0.075 mm or a smaller spacing. The gates are robust, they can be fabricated in less than 3 hours, and the method of production is reproducible. In time-of-flight mass spectrometers, fine wire spacing leads to improvements in mass resolution and modulation rates. Gates that were produced using this new method have been installed in a Hadamard transform time-of-flight mass spectrometer in order to demonstrate their utility.

Gate for modulating beam of charged particles and method for making same

A method and device for volatilizing and thereafter ionizing quantitatable femtomole and smaller amounts of molecules of nonvolatile solid oranic materials is disclosed. The method and device employ a laser pulse to desorb the organic material from a support upon which it is physisorbed. The support and the laser are related to provide a rate of heating of the support surface of at least 10.sup.6 .degree. K./sec with the support withstanding this heating rate without volatilization. Glass and similar inorganic oxidic substrates are preferred. The molecules so generated can be ionized, preferably with the use of resonance-enhanced muiltiphoton ionization. The ions so formed are characterized by a heavy predominance of ions corresponding to the molecules so as to permit their sensitive and unambiguous resolution by mass spectrometry.

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Villingen, Germany

Friedrich Engelke