Bayer Aktiengesellschaft

Farbenfabriken Bayer Aktiengesellschaft

Friedrich Bossert

Wulf Vater

Horst Meyer

Kurt Stoepel

Egbert Wehinger

Stanislav Kazda

Arend Heise

Robertson Towart

Gerhard Franckowiak

Siegfried Goldmann

Klaus Schlossmann

Matthias Schramm

Gunter Thomas

Hilmar Bischoff

Rainer Gross

Jurgen Stoltefuss

Horst Boshagen

Walter Puls

Dieter Petzinna

Bodo Junge

Harald Horstmann

Friedrich Hoffmeister

Joachim Bender

Hans J Ahr

Stanislav Kaada

Stanislay Kazda

Novel blood sugar-lowering dihydropyridinelactones of the formula ##STR1## in which R represents halogen, C.sub.1 -C.sub.10 -alkyl, C.sub.1 -C.sub.10 -alkoxy, C.sub.1 -C.sub.10 -alkylthio, C.sub.1 -C.sub.10 -alkylsulphinyl, C.sub.1 -C.sub.10 -alkylsulphonyl, cyano, C.sub.1 -C.sub.6 - mono- or polyfluoroalkyl, C.sub.1 -C.sub.6 -mono- or polyfluoroalkoxy or nitro,

Novel 1-alkyl-substituted 1,4-dihydropyridinelactone anti-diabetics

A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinforcing.

Mixture of different dihydropyridines

The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.

The compound,

Reducing blood sugar with the novel dihydropyridinelactols, or salts thereof, of the formula ##STR1## in which R.sup.1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radical, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano,

Dihydropyridinelactols and their use as medicaments which influence

Dihydropyridines of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.5 and R.sup.6 can be hydrogen or various halogen or organic radicals,

Circulation-active novel chromone- and thiochromone-substituted

The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.

Vasodilating cyanoalkyl esters of 1,4-dihydropyridines

1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, and

Method of combatting coronary and vascular diseases

1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic

The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10.degree. to 100.degree. C., of an ester group which contains an electron-attracting group. The invention also includes novel compounds made according to the invention as well as compositions containing said novel compounds. Also included in the invention are methods for the use of said compounds and compositions. The compounds obtained according to the process of the invention are useful because of their circulation-influencing action and are also useful as intermediates for the preparation of compounds having circulation-influencing action.

Production of 1,4-dihydropyridinecarboxylic acids

The invention provides pharmaceutical compositions and medicaments, useful for the treatment of cerebral disorders, wherein the active compound is 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine-3-(.beta.-methoxyethy l ester)-5-(isopropyl ester). Also included in the invention are methods for the use of said compositions and medicaments.

Cerebral therapeutic agent and its use

The invention includes new 1,4-dihydropyridazine compounds, compositions containing said 1,4-dihydropyridazine compounds and methods for the use of said compounds and compositions. Also included in the invention are methods for preparing the new 1,4-dihydropyridazine compounds.

1,4-Dihydropyridazine compounds, and their medicinal use

The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said compounds and compositions. The compounds of the invention are active as circulation-influencing and spasmolytically active agents.

1,4-Dihydropyridazine compounds

1,4-Dihydropyridinecarboxylic acids

The invention relates to 1,4-dihydro-pyridazine-3-carboxylic acid derivatives and compositions containing said derivatives. Also included in the invention are methods for the manufacture and use of said compounds and compositions. The derivatives of the invention influence the circulation and have a spasmolytic and anti-inflammatory action.

1,4-Dihydropyridazine-3-carboxylic acid derivatives, a process for their

The invention relates to fluorine-containing 1,4-dihydropyridine compounds and method for their preparation. Also included are compositions containing said fluorine-containing 1,4-dihydropyridine compounds and the use of said compounds and compositions as agents for influencing circulation.

Growing community of inventors

Wuppertal-Elberfeld, Germany

Friedrich Bossert