Degussa Aktiengesellschaft

Evonik Degussa Gmbh

Evonik Operations Gmbh

Evonik Technochemie Gmbh

Friedhelm Merz

Peter Werle

Martin Trageser

Andreas Karau

Dietmar Reichert

Guenter Knaup

Günter Knaup

Martin Sarich

Jolanta Habrich

Judith N J&oslash;rgensen

Christian Kessler

Disclosed herein is a cell culture media containing L-glutamine from a set of N-acylated dipeptides Acyl-X-Q, and L-glutamine from a set of other glutamine-sources Qsource in a defined molar ratio R=n(Acyl-X-Q)/n(Qsource), wherein the variables X, Q, Acyl, R, n(Acyl-X-Q) and n(Qsource) are defined in the general disclosure. Processes of using the cell culture media are also described herein.

Culture media comprising n-Acyl-X-glutamine dipeptides

5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.

Process for preparing 5-hydroxymethylfurfural via 5-acyloxymethylfurfural as an intermediate

The invention relates to water-soluble, chlorhexidine-containing compositions having a long shelf life. The compositions are in the form of powder, granules or tablets and consist substantially of (i) a salt of chlorhexidine with 2 moles of a sugar acid and a microbicidally active quaternary ammonium bromide, or of (ii) chlorhexidine, a sugar acid or sugar lactone, with at least 2 moles of sugar acid or sugar lactone being present per mole of chlorhexidine, and a microbicidally active quaternary ammonium bromide. Peferred compositions consist substantially of chlorhexidine digluconate and N-cetyl-N,N,N-trimethylammonium bromide (cetrimide) in a weight ratio of 1:1 to 1:10. The solid compositions are stable, with little or no p-chloroaniline splitting off during storage.

Water-soluble, chlorhexidine-containing compositions and use thereof

Powdered mixtures of chlorhexidine base with selected sugar acids or lactones from the group gluconic acid or gluconolactone, lactobionic acid (I), D-galactono-&ggr;-lactone (II), L-mannono-&ggr;-lactone (III), D-(&minus;)-gulono-&ggr;-lactone (IV), D-(&plus;)-galacturonic acid (V) and &agr;-D-heptaglucono-&ggr;-lactone (VI). The formulations have extraordinary storage stability. New chlorhexidine salts with sugar acid anions based on (I) to (VI) and aqueous solutions of these are also described. The formulations, solutions and pure salts are used as disinfectants and to prepare disinfectants.

Chlorhexidine formulations, new chlorhexidine salts, solutions containing these and their use

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Nierstein, Germany

Friedhelm Merz