Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Friedhelm Eisenbeiss

Dieter Lubda

Joachim Kinkel

Werner Gunkel

Werner Muller

Karl Siegfried Boos

Hans-Daniel-Jakob M&uuml;ller

Andreas Walfort

Helmut Kohl

Jochen Kinkel

A continuous process for the preparation of inorganic and organic bead polymers using a static micromixer is disclosed. The bead polymers obtainable by the process according to the invention have a very uniform particle size distribution, which can be set in a range of between 0.1 and 300 &mgr;m.

Method for producing bead polymers

The invention relates to improved chromatographic support materials, to the preparation thereof and to the use thereof as sorbent for chromatography. The particles of these materials have hydrophobic surfaces consisting of fatty acid esters in the pores and hydrophilic outer surfaces. The materials according to the invention permit direct separation of protein-containing samples by means of reverse phase methods.

Modified chromatographic support materials

A chromatography column cartridge system comprised of an internal pressure-stable precision glass tube which can be filled with adsorbent and an external protection and/or temperature control jacket with column connection parts which can be screwed on. The column connection parts comprise a union nut which is screwed onto the protection and/or temperature control jacket. The union nut contains a milled nut and a plunger which seals the glass tube radially. Feed and discharge lines for the mobile phase pass through the column connection parts.

Chromatography column cartridge system

A chromatography column adapted for high pressure chromatography is characterized by a tubular membrane separating a glass tube from the pressurized area between the glass tube and a pressure tube adapted to receive a pressurizing fluid. Changing of the glass tube is facilitated by annular seals at each end of the glass tube against which an adjustable threaded plug, fitted in one of a pair of screw caps fitted on each end of the pressure tube, exerts sealing pressure.

Chromatography column

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Weiterstadt, Germany

Friedhelm Eisenbeiss