Basf Aktiengesellschaft

Friedhelm Balkenhohl

Joachim Paust

Wolfgang Ladner

Bernhard Hauer

Walter Dobler

Uwe Pressler

Wolfgang Siegel

Klaus Ditrich

Horst Ralf Staudenmaier

Michael Hullmann

Peter Eckes

Ursula Schnell

Thomas Zierke

Udo Lange

Helmut Mack

Hartwig Voss

Thomas Pfeiffer

Werner Seitz

Stefan Koser

Christoph Nubling

Klaus Kaiser

Nicholas John Holman

Christoph N&uuml;bling

A process for preparing enantiomerically pure esters of the formula I (Ia and Ib)

Method for producing esters of triazolopyrimidine derivatives free of enantiomers using vinylesters with lipase

Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation

Process for preparing 3-pyrroline-2-carboxylic acid derivatives

Separation of optically active amides

Biotechnological perparation of alcohols, aldehydes and carboxylic acids

Resolution of the racemates of primary and secondary amines by

A process for preparing enantiomerically pure lactams of the formula I ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, H, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.2 -C.sub.4 -alkenyl, unsubstituted or substituted aryl, (CH.sub.2).sub.n --COOH with n=0, 1, 2, 3, and X is 1, 2, 3, 4, 5, from a racemate of the formula I by. allowing a biocatalyst which selectively converts one enantiomer from I to act on the racemic mixture of I, and isolating the unconverted enantiomer from the resulting mixture of products.

Preparation of enantiomerically pure lactams

(6S)-6,8-Dihydroxyoctanoic esters I ##STR1## (R.sup.1 =alkyl, cycloalkyl, aralkyl or aryl), are prepared by reducing a (3S)-3-hydroxyoctanedioic diester II ##STR2## (R.sup.2 =an R.sup.1 radical group) with a complex hydride and are mainly used as intermediates for synthesizing compounds of the type of liponic acid.

Preparation of (6s)-6,8-dihydroxyoctanoic esters

A process for preparing R/S-.gamma.-lipoic acid of the formula I or R/S-.alpha.-lipoic acid of the formula II ##STR1## is disclosed.

Preparation of R/S-.gamma.-lipoic acid or R/S-.alpha.-lipoic acid

A process for isolating the calcium salt of ascorbyl 2-monophosphate from aqueous alkaline reaction mixtures as are obtained on reaction of ascorbic acid with a molar excess of phosphorus oxychloride in the presence of a tertiary amine while maintaining a pH of from 12 to 13 during the reaction by means of an aqueous alkali metal hydroxide solution, which comprises a) starting from a reaction mixture which has been obtained by reacting ascorbic acid with phosphorus oxychloride in the presence of pyridine while maintaining a pH of from 12 to 13 by means of an aqueous potassium hydroxide solution, b) precipitating, as potassium magnesium phosphate, the phosphate ions which have been formed in this reaction by means of magnesium chloride in amounts of about 1 mol per mol of phosphate ions, c) removing the potassium magnesium phosphate, d) distilling the remaining aqueous solution to remove the pyridine together with part of the water, e) reacting the resulting aqueous solution with calcium chloride and f) isolating the calcium salt of ascorbyl 2-monophosphate which crystallizes thereby, or first distilling the pyridine-water mixture according to step (d) from the reaction mixture obtained in step (a) and thereafter carrying out steps (b), (c), (e) and (f).

Preparation of calcium L-ascorbate 2-phosphate

Potassium magnesium L-ascorbate 2-phosphate is prepared from an aqueous solution of potassium L-ascorbate 2-phosphate which is highly contaminated with KCl, as is produced in the phosphorylation of 5,6-isopropylidene-L-ascorbic acid, by adding to the solution about 1 equivalent of magnesium ions per equivalent of L-ascorbate 2-phosphate, and subsequently removing the KCl by electrodialysis. The product of this process is a novel salt of L-ascorbic acid 2-phosphate and has very advantageous handling properties.

Preparation of potassium magnesium L-ascorbate 2-phosphate

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Limburgerhof, Germany

Friedhelm Balkenhohl