Sanofi

Sanofi-Aventis

Frédéric Puech

Yulin Chiang

Jacques Froissant

Christian Hoornaert

Ahmed Abouabdellah

Frank Marguet

Philippe Burnier

Benoît Marabout

Zhongli Gao

Antonio Almario Garcia

Adrien Tak Li

Matthieu Barrague

Jean Jeunesse

Roy J Vaz

Antoine Ravet

Pascal George

Sylvain Cote Des Combes

Christophe Pacaud

Alain Gueiffier

Qiuxia Zhao

Jean-Francois Gibert

Cécile Enguehard

Sylvain Cote-Des-Combes

Sylvain Cote-Des Combes

Adrien-Tak Li

Larry Davis

Jean-François Gilbert

Compounds corresponding to the general formula (I) 

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The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof

The invention provides compounds of general formula (I) in whichX represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach independently of one another represent a hydrogen atom or a (C-C)alkyl group, or else Rand R, together with the nitrogen atom bearing them, form a pyrrolidinyl, piperidinyl, morpholinyl or 4-(C-C)alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type which may carry one or more halogen atoms and/or one or more (C-C)alkyl and/or (C-C)alkoxy groups; in the form of bases, addition salts with acids, solvates or hydrates; the pharmaceutical compositions comprising them, processes for preparing them, and synthesis intermediates.

3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments

The invention concerns compounds of general formula (I), wherein: X represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl group; Rand R, represent each, independently of each other, a hydrogen atom or a (C&#x2013;C)alkyl group, or Rand Rform, with the atom which bears them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl, pyridazinyl type, the heteroaromatic group may represent one or several halogen atoms and/or one or several (C&#x2013;C)alkyl, (C&#x2013;C)alkoxyl groups; in the form of bases, addition salts to acids, solvates or hydrates. The invention also concerns pharmaceutical compositions containing same, methods for preparing same and synthesis intermediates 

3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use

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Paris, France

Frédéric Puech