Bio-rad Laboratories, Inc.

Gothenburg Sensor Devices Ab

Insingulo Ab

Nanolyze Ab

Layerlab Aktiebolag

Fredrik Höök

Anders Lundgren

Anders Gunnarsson

Indriati Pfeiffer

Seyed Tabaei

Marta Bally

Magnus Brändén

Magnus Branden

Lisa Simonsson Nyström

Stephan Block

Björn Johansson Fast

Tim Kaminski

Björn Agnarsson

The disclosure concerns a method for determining the interaction between a test compound and a receptor. The receptor may be immobilized. The disclosure also concerns a sample holder assembly including a functionalized test well wall, which may be used in combination with a Total Internal Reflection Fluorescence source.

Method for determining the interaction between a ligand and a receptor

The disclosure relates to a method for determining a hydrodynamic size of an object, such as a nano-sized object, said method comprising the steps of: &#x2014;providing a fluid interface, &#x2014;linking said object to said fluid interface thereby providing a linked object, whereby the movement of said linked object is restricted by virtue of being linked to said fluid interface, &#x2014;providing and determining a hydrodynamic shear force that acts on said linked object, &#x2014;tracking the movement of said linked object, and &#x2014;calculating the hydrodynamic size of the object using the Einstein-Smoluchowski relation.

Method for determining a hydrodynamic size of an object

The present invention provides a method for studying transport of an agent across a membrane comprising the steps a) providing at least one surface with a bilayer structure tethered to the surface, said bilayer structure comprising a detection volume, b) contacting the bilayer with at least one agent to be analyzed, and c) detecting a change in refractive index in the detection volume resulting from transportation of the agent across the membrane. Further there is provided a device comprising a) at least one surface, b) at least one bilayer structure tethered to the surface, and c) at least one sensor capable of detecting a change in refractive index in a detection volume, wherein the bilayer structure encloses a first volume of the detection volume and wherein the volume not enclosed by the bilayer structure but within the detection volume is a second volume and wherein the ratio between the first volume and second volume is above about 0.001.

Method for studying transport of an agent across a bilayer membrane in bioanalytical sensor applications

A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.

Waveguide structure

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Alingsås, Sweden

Fredrik Höök