Washington University

Quretech Bio Ab

Nordic Chemquest Ab

Other

Saint Louis University

Fredrik Almqvist

Scott J Hultgren

Knut Irgum

Jerome Pinkner

Jonas Persson

Veronica Aberg

Andreas Larsson

Kjell Oberg

Christina Leigh Stallings

Nils Pemberton

Kelly Flentie

Gabriel Enrique Soto

Fritiof Pontén

Michael G Caparon

James Arthur Dudley Good

Gregory Alexander Harrison

Pardeep Singh

Aaron James Leonard Lynch

Souvik Sarkar

Ana Lidia Flores Mireles

Anders Lindgren

Magnus Sellstedt

Pralay Das

Kjell Öberg

Christina L Stallings

The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria

Described is a composition that includes: 

Ring-fused thiazolino 2-pyridones in combination with a drug against tuberculosis

The present disclosure provides a combination comprising: (i) a drug against tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable combination thereof. The combination may be used in the treatment and/or prevention of tuberculosis.

Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of tuberculosis

A device is provided for performing chemical transformation in a fluid, with a flow distributor having at least one fluid medium inlet, at least one fluid medium outlet, and at least one confinement wherein the chemical transformation is performed; and a means for rotating, rocking, wagging, or oscillating the device. At least one confinement may be equipped with a provision for providing heat, cooling, sound, light or other types of radiation, such provision being contacted to an external source through an actuator shaft. The flow distributor may be provided with sectors connected with the centrally located fluid medium inlet and a designated peripheral fluid medium outlet. The means for rotating, rocking, wagging, or oscillating the device may be an element producing magnetic fields or a shaft mechanically connected to an external actuating device.

Device for performing a chemical transformation in fluidic media

A device is provided for performing chemical transformation in a fluid, with a flow distributor having at least one fluid medium inlet, at least one fluid medium outlet, and at least one confinement wherein the chemical transformation is performed; and a means for rotating, rocking, wagging, or oscillating the device. At least one confinement may be equipped with a provision for providing heat, cooling, sound, light or other types of radiation, such provision being contacted to an external source through an actuator shaft. The flow distributor may be provided with sectors connected with the centrally located fluid medium inlet and a designated peripheral, fluid medium outlet. The means for rotating, rocking, wagging, or oscillating the device may be an element producing magnetic fields or a shall mechanically connected to an external actuating device.

The present invention relates to new compounds of the formula (I), (II), or (III) wherein R, R, R, R, Rand W are as defined herein, and pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A&#x3b2; amyloid disease, such as observed in Alzheimer's disease, infectious diseases, PAI-I related disease, and in the manufacture of medicaments for such treatment. 

Peptidomimetic compounds

Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit adherence of bacteria to a host cell.

Amino methylated 2-pyridinones

B-lactam-like chaperone inhibitors

Growing community of inventors

Umeå, Sweden

Fredrik Almqvist