University of Texas System

The Ohio State University

Nationwide Children's Hospital, Inc.

The Ohio State Research Foundation

Fredika Robertson

Lance A Liotta

Mauro Ferrari

John K Bauer

Pijus K Mandal

David Geho

John S McMurray

Ramesh Rajaopal

Zhiyong Ren

Mark Ming-Cheng Cheng

Giovanni Cuda

Marco Gaspari

Warren S Liao

Emmanuel Petricoin

Xiaomin Chen

Rosa Terracciano

Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors for interleukin-6 family cytokines, growth factors such as the platelet-derived growth factor, the epidermal growth factor, vascular endothelial growth factor, and other signaling molecules such as leptin. Blocking these interactions prevents STAT3 from being phosphorylated on Tyr705, which is required for the dimerization of STAT3, translocation to the nucleus, binding to STAT3 response elements on promotors, and transcription of genes. In addition to these activities, binding to the SH2 domain of STAT3 breaks up pre-formed dimmers, thereby preventing the transcriptional activity of the inhibitor.

Inhibitors of STAT3 and uses thereof

Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.

Nanoporous substrates for the analytical methods

Vascular endothelial growth factor alternative splice variants and methods of their use are provided.

Vascular endothelial growth factors and methods of their use

Growing community of inventors

Houston, TX, United States of America

Fredika Robertson