Institut Pasteur

Centre National De La Recherche Scientifique

Universite Paris 7

Frederik Kunst

Pierre Charneau

Frédéric Tangy

Chantal Combredet

Raymond Dedonder

Jean-Claude Manuguerra

Nicolas Escriou

Georges Rapoport

Andre Klier

Sylvie Van Der Werf

Benoît Callendret

Jean-Michel Betton

Valérie Lorin

Sylvie Gerbaud

Ana Maria Burguiere

Saliha Azebi

Jean-François Delagneau

Bernadette Crescenzo-Chaigne

Monique Martin

Antoine P Amory

The invention relates to a novel strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from a sample collected in Hanoi (Vietnam), reference number 031589, nucleic acid molecules originating from the genome of same, proteins and peptides coded by said nucleic acid molecules and, more specifically, protein N and the applications thereof, for example, as diagnostic reagents and/or as a vaccine.

Strain of SARS-associated coronavirus and applications thereof

The invention relates to any fragment of DNA derived from the genome of B. licheniformis coding for a polypeptide of 46 amino acids, or for any fragment of this polypeptide possessing the property of stimulating the production of enzymes secreted by B. subtilis by introduction of the above-mentioned fragment of DNA into this latter by the intermediary of a plasmid. The invention also relates to a procedure for the stimulation of the production of a specific polypeptide by B. subtilis by introduction of the above-mentioned fragment of DNA in a strain of B. subtilis, the genome of which has been modified so that it contains a sequence of DNA coding for the said specific polypeptide.

DNA sequence performing a function which is expressed in an

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Paris, France

Frederik Kunst