Janssen Pharmaceutica Nv

Tibotec Pharmaceuticals Ltd.

Frederik Frans Daeyaert

Paulus Joannes Lewi

Hendrik Maarten Vinkers

Paul Adriaan Janssen

Marc Rene De Jonge

Amuri Kilonda

Jerome Emile Guillemont

Elisabeth Therese Pasquier

Georges Joseph Hoornaert

Kurt Hertogs

Eva Bettens

Ruben Gerardus Leenders

Jan Heeres

Donald William Ludovici

Chih Yung Ho

Michael Joseph Kukla

Robert William Kavash

Paul A Janssen

Bart L De Corte

Lucien Maria Koymans

Koen Jeanne Van Aken

Paul Adrian Janssen

Frans Josef Compernolle

Dirk Alfons Vandenput

This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0, 1, 2, 3 or 4; R.sup.1 and R.sup.2 are each independently selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 -alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each of the aforementioned C.sub.1-12 alkyl groups may optionally and each individually be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl; and each R.sup.4 independently is hydroxy, halo, C.sub.1-6 alkyl, C.sub.1-6 -alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is --X--R.sup.5 or --X--Alk--R.sup.6 ; wherein R.sup.5 and R.sup.6 each independently are indanyl, indolyl or phenyl; each of said indanyl, indolyl or phenyl may be substituted; and X is --NR.sup.3 --, --NH--NH--, --N.dbd.N--, --O--, --S--, --S(.dbd.O)-- or --S(.dbd.O).sub.2 --; aryl is optionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and pharmaceutical compositions comprising them.

Trisubstituted 1,3,5-Triazine Derivatives

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Antwerp, Belgium

Frederik Frans Daeyaert