Novo Nordisk A/s

Novo Industri A/s

Frederik Christian Gronvald

Peter Faarup

John Bondo Hansen

Anthony Murray

Christian Grondahl

Jan Lund Ottesen

Lone Jeppesen

Flemming E Nielsen

John Patrick Mogensen

Jan Markussen

Anker S Jorgensen

Behrend Friedrich Lundt

Erling Guddal

Carsten Enggaard Stidsen

Karin D Jorgensen

Alister J Moody

Claus Braestrup

Nils L Johansen

Erik K Frandsen

Meiosis regulating compounds

Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.

Piperidine derivatives of formula ##STR1## wherein A is straight or branched alkyl, alkoxy-alkyl, or alkenyl; X is O or NH; Y is O, S, NH, NCN, or N-alkyl; R.sup.1 is 6-fluoro-1,2-benzisoxazol-3-yl, 6-fluoro-1H-indazol-3-yl, or 6-fluoro-1-methyl-1H-indazol-3-yl; R.sup.2 is alkyl or phenyl; and R.sup.3 is phenyl optionally substituted, or R.sup.3 is ##STR2## wherein Z represents a 5- or 6-membered heterocyclic ring; or R.sup.2 and R.sup.3 together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.

Piperidine derivatives

The present invention relates to therapeutically active piperidine derivatives, of formula 1 ##STR1## wherein, R.sup.1, R.sup.2, A, X and Y are as defined in the specification. The compounds are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.

Antipsychotic piperidine derivatives

Novel [1]benzothieno[2,3-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof of the general formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, halogen, alkyl, alkoxy or trifluoromethyl. The compounds are useful for treating a central nervous system ailment associated with the NMDA receptor-associated glycine site.

Benzothienopyrazinedione compounds and their preparation and use

1-Aminobut-3-en derivatives having optionally substituted furanyl, thienyl, pyridyl and/or pyrrolyl in the 4-position and 3-carboxypiperidin-1-yl, 3-carboxytetrahydropyrid-1-yl or 3 carboxymethylpyrrolidin-1-yl in the 1-position potentiate GABA-ergic neurotransmission.

N-(butenyl substituted) azaheterocyclic carboxylic acids

Certain peptides containing the glucagon.sub.1-21 peptide chain His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Al a-Gln-Asp, usable as a medicament or a diagnostic; the peptide exerts a spasmolytic effect and an inhibitory effect on gastric acid secretion similar to glucagon with not more than a negligible metabolic effect. Some of the glucagon fragments are novel compounds.

Use of peptides as medicaments and certain novel peptides

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Vedbaek, Denmark

Frederik Christian Gronvald