Amgen Inc.

Frederick W Jacobsen

Taruna Arora

Hailing Hsu

Kenneth William Walker

Ian Nevin Foltz

Thomas Charles Boone

Gunasekaran Kannan

Yue-Sheng Li

Wayne H Tsuji

Ming Zhang

HoSung Min

Jane Talvenheimo

Hsieng Sen Lu

William Gleason Richards

Hua Zhu Ke

Chaoyang Li

George Doellgast

George (deceased) Doellgast

Kenneth W Walker

Thomas C Boone

Anja Leona Biere-Citron

Stephen J Wood

Ho-Sung Min

Jennifer Lavallee

Hosung Min

Wayne Tsuji

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.

DKK1 antibodies and methods of use

Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.

Proteins specific for BAFF and B7RP1 and uses thereof

Proteins specific for BAFF and B7RP1

Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

Carrier immunoglobulins

Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

Carrier immunoglobulins and uses thereof

There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.

Methods of using an alpha-4-beta-7 heterodimer specific antagonist antibody

Alpha-4-beta-7 heterodimer specific antagonist antibody

Growing community of inventors

Newbury Park, CA, United States of America

Frederick W Jacobsen