Cytomx Therapeutics, Inc.

Frederick W Gluck

James William West

Jason Gary Sagert

Nancy E Stagliano

Patrick Sean Daugherty

Paul Henry Bessette

Kathryn Kamath

The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.

Growing community of inventors

Santa Barbara, CA, United States of America

Frederick W Gluck