Scholar Rock, Inc.

Frederick Streich, Jr

Thomas Schurpf

Justin W Jackson

Stefan Wawersik

Abhishek Datta

Christopher Littlefield

Caitlin Stein

Matthew Salotto

Julia McCreary

George Coricor

Adam Fogel

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGFβ and uses thereof

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGF&#x3b2; and/or LTBP3-TGF&#x3b2;. The application also provides methods of use of these inhibitors for, for example, inhibiting TGF&#x3b2; activation, and treating subjects suffering from TGF&#x3b2;-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGF&#x3b2; inhibitor for a subject in need thereof are also provided.

LTBP complex-specific inhibitors of TGF&#x3b2; and uses thereof

Growing community of inventors

Newton, MA, United States of America

Frederick Streich, Jr