Micromed

University of Louisville Research Foundation, Inc.

Frederick N Miller

Thomas A Albert

A time-varying image of a circulating venue containing a flow of particles is generated by imaging using a video camera and a digital frame grabber. Spatio-temporal intensity gradients within each of the images are generated. Particles are then identified within the images. A particle is matched with a corresponding identical particle from other images using, for example, a heuristic equation that measures similarity of shape, size, and position. The distance of translation of the matched particle from one image to another is determined. Leukocyte velocity is determined by dividing the translation distance by the time differential between the images. The first five statistical moments of frequency distribution of the velocity may also be determined.

Method and apparatus for automated rolling leukocyte velocity measurement in vivo

A micro lysis and analysis process applying precise quantities of focused energy, such as light energy, to a precise microscopic area of a very small cell sample to activate an energy sensitive agent, such as a fluorescing agent, which permits measurement of cell fragility providing a means for determining the sensitivity of cells to particular chemicals, drugs, and/or diseases and the susceptibility and/or exposure of the cells to same.

Micro lysis-analysis process to measure cell characteristics

Micro lysis-analysis process to measure cell characteristics and

A method of determining cell membrane strength is disclosed, using focused light of selected frequency and energy density. The method is also useful in diagnosing the presence of certain diseases in cells, by comparing the membrane strength of cells exposed to cell-characteristic altering drugs to the membrane strength of a control group of cells.

Microphoto lysis-anlaysis process to measure cell characteristics

A microphotolysis and microphotoanalysis process applying precise quantities of focused light energy to a precise microscopic area of a very small cell sample to activate a chemical agent which permits measurement of cell fragility.

Growing community of inventors

Louisville, KY, United States of America

Frederick N Miller