The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Rhode Island Hospital, a Lifespan-partner

The Broad Institute, Inc.

Other

University of California

Massachusetts Institute of Technology

Northeastern University

Temple University

The United States of America As Represented by the Secretary of

Commonwealth Scientific and Industrial Research Organisation

Emory University

The Netherlands Cancer Institute

The General Hospital Corporation & Brigham and Women's Hospital

Frederick M Ausubel

Eleftherios Mylonakis

Dennis L Kasper

Lawrence C Madoff

James L Michel

Michael Nicholas Mindrinos

Brian J Staskawicz

Laurence G Rahme

Fumiaki Katagiri

Man-Wah Tan

Wooseong Kim

Guo-Liang Yu

Edward Holson

Gary B Ruvkun

John M Salmeron

William Martin Wuest

Douglas Dahlbeck

Barbara J Baker

Andrew F Bent

Barbara N Kunkel

Jeffrey Ellis

Jacqueline E Heard

Howard M Goodman

Kim Lewis

Georg Jander

Stephen B Calderwood

Terence I Moy

Eliana Drenkard

Costi D Sifri

Eva Huala

Shalina Mahajan-Miklos

Ronald W Davis

Suresh Gopalan

Peter Scott Yorgey

Read Pukkila-Worley

Helen Burgwyn Fuchs

Dennis Kim

Alejandro Aballay

Mary C Wildermuth

Julia Dewdney

Andrew Diener

Julia Plotnikova

Annie Conery

Hui Cao

Danielle A Garsin

John Tsongalis

Raj Mohan Raja Muthiah

Lisa Albright

Qing Gu

Eric J Richards

Annegien Broeks

Daphne Preuss

Ronald H A Plasterk

Tai-Ping Sun

Rhonda Feinbaum

Man Wah Tan

Genviève Alloing

The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by

Antibiotic compounds

The present application provides that synthetic retinoid compounds are useful in methods of treating bacterial infections, such as a bacterial infection caused by, methicillin-resistant(MRSA), vancomycin-resistant(VRSA),, and. The present application also provides a tricyclic fluoroquinolone compound, Z3060, useful in methods of treating bacterial infections, such as a bacterial infection caused by, methicillin-resistant(MRSA), vancomycin-resistant(VRSA),. spp.,, and. Also provided herein is a gold compound, auranofin, useful in treating bacterial and fungal infections, such as a fungal infection caused by, and

Antibacterial and antifungal compounds

The present application provides compounds of formula: Methods of using these compounds for killing bacterial growth and treating bacterial infections are also provided.

Antibacterial compounds

Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.

Modified saponins for the treatment of fungal infections

The invention features compounds that have antibacterial activity, their use for the treatment of bacterial infections, screening methods that use whole animals or plant seedlings to identify compounds that inhibit a pathogen in the animal or plant, and screening methods to identify compounds that increase the lifespan of an organism.

Methods for screening antimicrobial and antiviral compounds and uses thereof

This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections.

Antimicrobial compounds

The invention generally provides a novel approach to identifying Enterococcal virulence factors and for identifying compounds for treating bacterial pathogenesis. The invention further provides Enterococcal virulence factors, which serve as targets for drug discovery.

Photolyase nucleic acids

The invention relates to a method of identifying a plant disease-resistance gene that includes the steps of (a) providing a plant tissue sample; (b)introducing by biolistic transformation into the plant tissue sample a candidate plant disease-resistance gene; (c) expressing the candidate plant disease-resistance gene within the plant tissue sample; and (d) determining whether the plant tissue sample exhibits a disease-resistance response, whereby a response identifies a plant disease-resistance gene.

Methods of identifying plant disease-resistance genes

Screening procedures are disclosed for identifying compounds useful for inhibiting infection or pathogenicity. Methods are also disclosed for identifying pathogenic virulence factors.

Methods of screening compounds useful for prevention of infection or pathogenicity

Disclosed are methods for identifying nematodes having enhanced susceptibility to a pathogen; for identifying pathogen defense response genes; and for identifying compounds that enhances a host's defense response to a pathogen.

Methods for screening and identifying host pathogen defense genes

Disclosed are screening methods for identifying the interplay between environmental and host signals (e.g., host-dependent or host-independent signals) and physiological pathogenic pathways that control or regulate genes responsible for establishing a persistent infection, as in the colonization of the gut of the nematode.

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The invention provides methods for inducing or increasing disease resistance in a plant. The invention also features methods of using a plant having a mutation in an inducible isochorismate synthase to determine if the success of a pathogen in infecting a plant is affected by a plant disease resistance pathway involving isochorismate synthase.

Salicylic acid biosynthetic genes and uses thereof

Growing community of inventors

Newton, MA, United States of America

Frederick M Ausubel