Intelligent Medicine, Inc.

Frederick L Stone

David C Howson

John A Popken

Robert E Havranek

A storage receptacle sealing and transfer apparatus is disclosed for selectively enabling sealing and transfer of material to and from the receptacle. The apparatus is particularly useful for maintaining and later transferring drug and associated materials, under sterile conditions, to achieve mixing, as, is necessary, for example, in reconstituting a drug by mixing the drug with a diluent prior to delivery to a patient. The transfer apparatus is mounted at the aperture, or mouth, of a storage receptacle to seal the aperture until the contents are needed, and then to permit sterile transfer from one receptacle to another receptacle through a central passage. The apparatus also includes venting through one or more passages offset from the central passage for supplying or discharging air into the storage receptacle as needed, and a filter is included in each vent passage, with the filter being permeable to passage of gases, including air, in either direction through the vent passage, but precluding passage of liquid or solid materials or microorganisms in either direction through the vent passage. The central passage and all venting passages are sealed until use, and the central passage also includes a septum in one disclosed embodiment, with a penetrating unit being included for access through the septum to the interior of the storage receptacle for delivery or withdrawal of substance therefrom.

Storage receptacle sealing and transfer apparatus

An infusion device is disclosed having an improved valving apparatus with the valving apparatus being configured to substantially preclude formation of volumetric dead spaces. The valving apparatus is typically utilized to allow introduction of one or more secondary fluids, such as drugs, into a patient during normal infusion of the primary fluid into the patient, with such insertion being effected through a secondary conduit connected to the primary infusion conduit through the valving apparatus. The valving apparatus includes a movable element that is positioned adjacent to the inner wall of the primary conduit so that the movable element forms a one-way valve thereat. The movable element is partially displaced due to flow of secondary fluid through the secondary conduit toward the primary conduit to thereby allow the secondary fluid to pass by the movable element and enter the primary conduit, but the movable element cannot be displaced by flow within the primary conduit and therefore prevents passage of fluids through the valving apparatus from the primary conduit to the secondary conduit. When not displaced due to flow of secondary fluid through the valving apparatus into the primary conduit, the movable element is positioned near the inner wall of the primary conduit to substantially preclude formation of volumetric dead spaces thereat.

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Boulder, CO, United States of America

Frederick L Stone