Alza Corporation

Frederick H Maruyama

James B Eckenhoff

Jeremy C Wright

Judy A Magruder

John R Peery

Richard Lewis Cortese

John R Perry

The present invention is concerned with improving the delivery of a drug from a ruminal delivery device to give a consistent delivery of drug to the ruminal environment. Thus, the invention is directed to an improved ruminal drug delivery device comprising a semipermeable membrane having an exit orifice and defining a compartment, the compartment containing a swellable osmotic agent expandable driving member, a drug to be dispensed, a density element and, optionally, a partition layer between the osmotic expandable driving member and the drug formulation, wherein the improvement comprises an essentially gas-impermeable barrier means that separates the density element from the other components within the delivery device for isolating gases evolved from the density element from the other components within the delivery device. The barrier means further includes a coupling to transfer osmotic pressure to the semipermeable wall. The invention is also directed to methods and articles for providing a consistent delivery of drug from a ruminal drug delivery device.

Ruminal drug delivery device

The present invention is directed to an improvement in a delivery system, the system comprising a wall that surrounds an internal lumen or compartment which contains a thermo-responsive beneficial agent formulation, an expandable driving member and an optional density member, and having an exit opening, and wherein the improvement comprises a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive beneficial agent composition for increasing the viscosity of the beneficial agent composition, and/or b) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen.

Delivery system comprising means for controlling internal pressure

A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.

Delivery system with thermoresponsive composition comprising means for

The present invention is directed to an active agent dispenser for use in a fluid-containing environment, which dispenser comprises a rigid housing, a plurality of movable active agent units filling a portion of the housing, a fluid-activated driving member for dispensing the active agent units filling the remainder of the housing, and an active agent unit outlet means. In the present invention, each active agent unit is comprised of an active agent dosage or filling contained within a fluid-impermeable cup-shaped member, the cup-shaped members being oriented within the housing with the base of the cup-shaped members facing the outlet means.

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San Jose, CA, United States of America

Frederick H Maruyama