The General Hospital Corporation

Frederick Albert Schroeder

Changning Wang

Jacob Matthew Hooker

Jacob M Hooker

Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein Ris a moiety including a positron emitter; Rrepresents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), Ris a moiety including an adamantyl group.

Imaging histone deacetylases with a radiotracer using positron emission tomography

Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein Ris a moiety including a positron emitter; Rrepresents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), Ris a moiety including an adamantyl group. 

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Baltimore, MA, United States of America

Frederick Albert Schroeder