E.i. Dupont De Nemours and Company

Millennium Pharmaceuticals Limited

Rhodia Chirex, Inc.

Frederick A Hicks

Maurice S Brookhart

Shomir Ghosh

Kenneth Gordon Carson

Dominic J Reynolds

Kevin Sprott

Amy M Elder

Sean J Harrison

Christelle C Renou

Salvatore Anthony Marchese

Atena Necula

Lawrence J Martel

Da-Ming Gou

Richard A Silva

Richard E Benetti

Disclosed herein are compounds represented by Structural Formula (I) and (I-A):  Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply 'CRTH2' for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.

PGD2 receptor antagonists for the treatment of inflammatory diseases

Selected nickel complexes of the anions of certain 2-aminotropones are olefin polymerization catalysts. Novel 2-aminotropones and their nickel complexes are also disclosed together with methods of making these 2-aminotropones.

Catalysts for olefin polymerization

A method for making an indole compound includes transition metal-catalyzed arylation of a hydrazone to form an aryl hydrazone, hydrolysis of the aryl hydrazone to form an aryl hydrazine, and acid catalyzed cyclization of the aryl hydrazine to form the indole compound.

Method for making aryl hydrazines and substituted indoles

Catalysts for olefin polymerizations

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Somerville, MA, United States of America

Frederick A Hicks