Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Institut Gustave Roussy

Frederic Taran

Jean-Christophe Cintrat

Eric Deutsch

Catherine Brenner

Jean Luc Perfettini

Aloïse Mabondzo

Sergii Kolodych

Sophie Dezard

Manon Chaumontet

Evelia Rasolofonjatovo Andovola

Alexandra Trotier-Faurion

Aloise Mabondzo

The present invention is drawn to the use of Minaprine dihydrochloride and analogs thereof, for reducing tumor growth when administered to a patient suffering from cancer.

Use of minaprine to reduce tumor growth

The present invention is drawn to the use of the compounds highlighted in Tables 1 & 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called 'enhancers of IR-mediated cellular cannibalism'. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.

Enhancers of cellular cannibalism for use to sensitize tumors to radiation therapy

The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group and of formula R'&#x2014;OH in which R&#x2032; represents a hydrocarbon radical containing at least 4 carbon atoms. The present invention also concerns particular creatine fatty esters or derivative thereof and medical uses thereof.

Method for preparing creatine fatty esters, creatine fatty esters thus prepared and uses thereof

A method for preparing a pyrazole of formula (I) in which R,R' and R&#x2033; have different meanings, characterised in that it involves reacting a sydnone of formula (II) in which R and R&#x2032; have the meanings already indicated, with an alkyne of formula (III) in which R&#x2033; has the meaning already indicated, in the presence of copper, to obtain a pyrazole compound of formula (I) that is then isolated and salified if desired. 

Method for producing pyrazoles, novel pyrazoles and applications thereof

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Gif sur Yvette, France

Frederic Taran