Sanofi Pasteur Inc.

Centre National De La Recherche Scientifique

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Biomerieux, Inc.

Universite Claude Bernard – Lyon1

Agence Francaise De Securite Sanitaire Des Aliments

Frederic Ronzon

Herve Perron

Philippe Peltie

Anthony William Coleman

Vincent Poher

Eric Da Silva

Marilyne Dupin

Isabelle Chacornac

Sandrine Lentsch Graf

Aly Moussa

Ambroise Martin

Frederic Fantoni

Nabila Ikhelef-Gribi

Julien Tirefort

Edwige Leclere

Christian Valentin

Anna Benscik-Reynier

The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon&#x2122; and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.

Method of storing a vaccine containing an aluminum adjuvant

The invention relates to a method for estimating the amount of entities deposited on microparticles in suspension in a solution, and also to an associated device. The method comprises the following steps:

Method for estimating the amount of entities deposited on microparticles in suspension in a solution, associated device and use of said device

The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.

Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand

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Montromant, France

Frederic Ronzon