Sanofi-aventis

Sanofi

Frederic Puech

Jacques Froissant

Frank Marguet

Philippe Burnier

Benoit Marabout

Christian Hoornaert

Adrien Tak Li

Yulin Chiang

Ahmed Abouabdellah

Jean Jeunesse

Sylvain Cote Des Combes

Christophe Pacaud

Antoine Ravet

Pascal George

Jean-Francois Gibert

Antonio Almario-Garcia

Sylvain Cote-Des-Combes

Anne Olivier-Bandini

Compounds corresponding to the general formula (I) wherein Rrepresents a group C-alkyl, C-cycloalkyl, C-cycloalkyl-C-alkyl, C-alkyl-C-cycloalkyl, C-cycloalkyl-C-cycloalkyl, C-alkylthio-C--alkyl, C-alkoxy-C-alkyl, hydroxy-C-alkyl, hydroxy-C-alkyl-C-cycloalkyl-C-alkyl, hydroxy-C-cycloalkyl, C-fluoroalkyl or C-fluorocycloalkyl; an optionally substituted heterocyclic group; a group C-alkyl substituted with an optionally substituted heterocyclic group; Xrepresents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C-alkyl, C-cycloalkyl, C-cycloalkyl-C-alkyl, C-fluoroalkyl or cyano; and Rrepresents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents,in the form of the base or of an acid-addition salt, and the therapeutic use thereof.

3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta

The invention relates to the 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]-pyridazine and derivatives thereof preparation and therapeutic application thereof

The invention relates to 6-cycloamino-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to the general formula (I) in which Rrepresents an aryl group optionally substituted with one or more halogen atoms or C-alkyl, C-alkyloxy, C-alkylthio, C-fluoroalkyl, C-fluoroalkyloxy and &#x2014;CN groups or Rrepresents a group chosen from C-alkyl, C-fluoroalkyl, C-cycloalkyl or C-cycloalkyl-C-alkyl groups; A represents a C-alkylene group; B represents a C-alkylene group; L represents either a nitrogen atom optionally substituted with an Ror Rgroup, or a carbon atom substituted with an Rgroup and an Rgroup or two Rgroups; the carbon atoms of A and of B being optionally substituted with one or more Rgroups, which may be identical to or different from one another. Preparation process and therapeutic use. 

[object Object]

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and derivatives and pharmaceutical compositions comprising the same

Therapeutic uses of a compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C-C-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.

Therapeutic uses of derivatives of piperidinyl- and piperazinyl-alkyl carbamates

A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom;Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach represent, independently of one another, a hydrogen atom or a (C-C)alkyl group or else Rand Rform, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C-C) alkyl or (C-C) alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use

The invention concerns compounds of general formula (I): Wherein n, X, Y, Rand Rare as defined herein. The invention also concerns a method for preparing the compounds and their therapeutic use.

1H-pyrimido[4,5-b]indole derivatives, their preparation and therapeutic use

The invention relates to a compound of formula (I): Wherein R, R, Rand Rare as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.

Alkyl-, alkenyl- and alkynylcarbamate derivatives, their preparation and their application in therapeutics

The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R, Rand Rare as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.

3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics

A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; Rrepresents a hydrogen atom or a (C-C)alkyl group; Rand Reach represent, independently of one another, a hydrogen atom or a (C-C)alkyl group or else Rand Rform, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C-C)alkyl or (C-C)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.

Compound corresponding to the general formula (I): in which A=N or CR; R=H, F, OH, CN, CF, C-alkyl, C-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR; B=covalent bond or C-alkylene; R=optionally substituted heteroaryl; R=CHRCONHR; R=H or C-alkyl; R=H, C-alkyl, C-cycloalkyl, C-cycloalkyl-C&#x2013;C-alkylene; in the form of a base, an acid-addition salt, a hydrate or a solvate. Therapeutic uses thereof.

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Gif sur Yvette, France

Frederic Puech