Institut National De La Sante Et De La Recherche Medicale

Universitë De Bordeaux

Op2 Drugs

Centre Hospitalier Universitaire De Bourdeaux

Other

Centre Hospitalier Universitaire De Bordeaux

Eurosurgical Sa

Frédéric Marin

Olivier Petitjean

Philippe Diolez

Dominique Detaille

Guy Viart

The present invention relates to desmethylanethole trithione (AOX) and derivatives thereof, especially derivatives of formula (I), for the prevention and treatment of diseases whose initiation and/or evolution relates to the production and effects of reactive oxygen species (ROS) of mitochondrial origin, 

Desmethylanethole trithione derivatives for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production

The present invention relates to the use of compounds for the prevention and treatment of diseases whose initiation and/or evolution relates to the production and effects of reactive oxygen species (ROS) of mitochondrial origin.

Compounds for the treatment of diseases linked to mitochondrial reactive oxygen species (ROS) production

The invention concerns an intervertebral disc prosthesis comprising an upper plate ( ) and a lower plate ( ) anchored respectively on the upper end-plate and the lower end-plate of the vertebral bodies of the vertebrae lying above and below a spine, a central core ( ) placed between the two plates ( ) which have an upper spherical cap ( ) and a lower spherical cap ( ) co-operating respectively with the spherical impressions ( ) arranged in said upper and lower plates, and an annular element ( ) made of viscoelastic material which is centred about the core ( ) and is urged into contact with protuberances ( ) provided on each internal surface ( ) of the upper plate ( ) and of the lower plate ( ) so as to limit and control the bending, inclining and rotating movements of the upper plate ( ) and of the lower plate ( ) relative to each other and about the core ( ), and ensure the positioning stability of the core ( ) between the two plates ( ) and prevent fibrous deposits from penetrating inside the prosthesis ( ).

Intervertebral disc prosthesis

Growing community of inventors

Paris, France

Frédéric Marin