Centre National De La Recherche Scientifique

Affymetrix, Inc.

Panomics, Inc.

Active Motif, Inc.

Centre National De Larecherche De La Recherche

Centre De La Recherche De La Scientifique

Frédéric Heitz

Gilles Divita

May Catherine Morris

Gudrun Aldrian-Herrada

Catherine May Morris

Federica Simeoni

Jean Mery

Joseph M Fernandez

John Archdeacon

Christian Devaux

Véronique Hebmann

Roger S Goody

Kyle Horndorp

Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKRKRKVRand an appropriate siRNA, wherein Rrepresents any amino acid residue and more preferably K or S, Ris null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C-Calkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.

Methods and compositions for delivering siRNA into mammalian cells

The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLXRALXRXLXRSLXXXXXXX(SEQ ID No: 1), wherein Xis A, L or G, Xis W or none, Xis R or K, Xis K, L or S, Xis L or K, Xis R or W, Xis K or S, and Xis A, V or Q, and Xis W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

Cell penetrating peptides for intracellular delivery of molecules

The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLXWRAXWRXLXRSLXWXXXXXX(SEQ ID No: 1), wherein Xis A, L or G, Xis W or none, Xis R or K, Xis K, L or S, Xis L or K, Xis R or W, Xis K or S, and Xis A, V or Q, and Xis W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

The invention is drawn to a novel class of drugs directed against HIV, comprising a peptide or analog comprising a decapeptide, said decapeptide containing (from N-terminus to the C-terminus) a basic amino acid in position 1, an acidic amino acid in positions 2 and 5, and a tryptophan in positions 4, 7, and 8, and to a method of treatment of HIV infections, in particular multidrug-resistant HIV infections.

Antiviral peptides obtained from the tryptophan-rich hydrophobic cluster of the HIV-1 reverse transcriptase

Peptide carrier for delivering siRNA into mammalian cells

Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. Claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.

Peptide-mediated transfection agents and methods of use

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Grabels, France

Frédéric Heitz