Dana-farber-cancer Institute Inc.

Children's Medical Center Corporation

Frederic Feru

David A Scott

Ofer Levy

David J Dowling

Francesco Borriello

Spencer E Brightman

Provided herein are imidazopyrimidine compounds, such as compounds of Formula (I), for use in enhancing human immune response and/or as adjuvants in vaccines.

Composition comprising an antigen and a substituted imidazo[1,2-a]pyrimidine for enhancing human immune response

The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein are used as enhancers and/or modifiers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease), or as stand alone anti-infective or immune response modifying agents. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. 

Imidazopyrimidine compounds and uses thereof

Growing community of inventors

Boston, MA, United States of America

Frederic Feru