Commissariat a L'energie Atomique

Université Pierre Et Marie Curie (paris Vi)

Sanofi-aventis

Frederic Dolle

Frank Marguet

Bertrand Tavitian

Alain Sanson

Francoise Ochsenbein

Jesus Benavides

Herve Boutin

Marie-Noelle Castel

Annelaure Damont

Thomas Rooney

Cyrille Thominiaux

The present invention relates to a peptide labelled with fluorine-18 for the specific recognition of lipid vectors. The peptide of the invention comprises the following peptide sequence (PI): in which the amino acids J are chosen independently of each other from natural amino acids, or derivatives thereof, in such a manner that at least 50% of them are polar residues chosen from Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr, the amino acids U are chosen from Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid Xis chosen independently of the other amino acids of the sequence from Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr and Val, the amino acid Bis chosen independently of the other amino acids of the sequence from Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr and Val, the amino acid Zis chosen independently of the other amino acids from Asp and Glu, the amino acids Zand Zare chosen independently from Glu, Asp, Lys and Arg, the superscripts of the residues J, Z, U, X and B representing the positions of these amino acids in the said sequence.

Marked peptides having affinity for a phospholipid and uses

Fluorine-18-labelled maleimide compounds of general formula (I): in which:  Process for preparing these compounds; their use for labelling macromolecules, and complexes of these compounds with a macromolecule. Detection and analysis kit, or diagnosis kit, comprising the said complexes. Use of the complexes in a medical imaging process such as positron emission tomography (PET).

Marked maleimide compounds, method for preparing same and use thereof for marking macromolecules

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Gometz le Chatel, France

Frederic Dolle