Sanofi-aventis

Eukarion, Inc.

Frédéric Cosledan

Bernard Meunier

Jérôme Cazelles

Alain Pellet

The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.

Dual molecules containing peroxy derivative, the synthesis and therapeutic applications thereof

The invention relates to compounds which are orally bioavailable water soluble metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halogen substituted alkyl or substituted or unsubstituted phenyl groups, are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.

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Labège, France

Frédéric Cosledan