Hoffmann-la Roche Inc.

Fred Thomas Bizzarro

Ramakanth Sarabu

Nancy-Ellen Haynes

George W Holland

Robert Francis Kester

Wendy Lea Corbett

Joseph Francis Grippo

Paige Erin Mahaney

Antonio Focella

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

Heteroaromatic glucokinase activators

Urea derivatives

Para-alkyl, aryl, cycloheteroalkyl or heteroaryl &lsqb;carbonyl or sulfonyl&rsqb; amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.

Para-amine substituted phenylamide glucokinase activators

2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.

Growing community of inventors

Colonia, NJ, United States of America

Fred Thomas Bizzarro