Twenty Twenty Therapeutics LLC

Verily Life Sciences LLC

Fred Shungneng Lee

Dimitri T Azar

Timothy D Stowe

In some aspects, an electronic contact lens for treating dry eye is presented. According to some aspects, the electronic contact lens includes a concave surface configured to conform to an eye of a patient, a sensor configured to generate a signal indicative of an eyelid movement, and at least one capacitor configured to store energy used for stimulating the eye. The electronic contact lens may further include at least two electrodes coupled to the at least one capacitor, wherein the at least two electrodes are exposed to the concave surface and configured to deliver power from the at least one capacitor to stimulate the eye. The electronic contact lens further includes a processor coupled to the sensor and electrodes. The processor may be configured to compute a blink rate from the sensor output, and, based on the blink rate, activate the at least two electrodes to stimulate the eye.

Ophthalmic devices, systems and methods for treating dry eye

A device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

Therapeutic devices for placement underneath the eyelid and associated systems, devices, and methods for dry eye treatment

According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.

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Sunnyvale, CA, United States of America

Fred Shungneng Lee