University of Colorado

Fred R Hirsch

Paul A Bunn, Jr

Wilbur Franklin

Mark W Geraci

Marileila Varella Garcia

Federico Cappuzzo

Paul A Bunn

Christopher D Coldren

Barbara A Helfrich

Razvan Lapadat

Michio Sugita

Samir E Witta

Wilbur A Franklin

Disclosed are methods to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer.

Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by non-small cell lung cancer patients

Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to gefitinib and other EGFR inhibitors, and products and processes related thereto. Specifically, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for the detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described.

Gefitinib sensitivity-related gene expression and products and methods related thereto

Growing community of inventors

Denver, CO, United States of America

Fred R Hirsch