Alcon Laboratories, Inc.

Fred M Killinger

Haresh G Bhagat

Don A Clements

Philip D Gressel

Robert E Beck

Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.

Physiological tear compositions and methods for their preparation

A multiple use container for dispensing fluids, particularly preservative free preparations in variable doses, includes a squeezable container for holding the fluid. A dispenser assembly associated with an exit opening from the container includes a hollow dispensing tip which encloses a fluid valve. The fluid valve utilizes a piston head which sealingly seats in a valve seat. A resilient biasing means holds the piston head in a normally sealed or closed position. A second opening in communication with the interior of the bottle is covered by a hydrophobic filter having a pore size that prevents microbial contaminants from entering the container but prohibits fluid from leaving the container. The bottle is squeezed to force fluid to overcome the biasing pressure of the fluid valve to dispense fluid from the bottle. Upon release of that pressure, the fluid valve closes and air passes through the filter to replace the dispensed fluid. The air entering the container is sterilized by the filter.

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Arlington, TX, United States of America

Fred M Killinger