Warner-lambert Company

Fred M Hershenson

Donald E Butler

Michael R Pavia

Om Prakash Goel

Michael Huai Gu Chen

Zhijian Zhu

Oilun Helen Chan

Prodrugs of benzofuranylethyl carbamate NK1 antagonists

Benzobicyclic lactam acids having a fused aromatic carbocyclic and a saturated lactam ring of five- or six-members, their salts, esters, and amides, are useful in the treatment of senility and for reversing amnesia. Pharmaceutical compositions including these compounds, a method of preparing the compounds, and a method of treating senility and reversing amnesia area also disclosed.

1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and

Benzobicyclic lactam acids having a fused aromatic carbocyclic and a saturated lactam ring of five- or six-members, their salts, esters, and amides, are useful for reversing amnesia. Pharmaceutical compositions including these compounds, a method of preparing the compounds, and a method of treating senility and reversing amnesia are also disclosed.

Benzobicyclic lactam acids and derivatives as cognition activators

A class of novel fused-ring, benzotricyclic, nitrogen-containing diones useful as agents in reversing electroconvulsive shock-induced amnesia. A method of preparing the compounds, pharmaceutical compositions including the compounds, and a method of reversing electroconvulsive shock-induced amnesia are disclosed.

Benzotricyclic nitrogen-containing diones and their use in reversing

N-[1-oxo-3-(5-oxo-2-pyrrolidinyl)propyl]-alpha-aminoacids, base addition salts, esters, and amides are useful as cognition activators. Pharmaceutical compositions containing these compounds and methods of using the pharmaceutical compositions for treating senility or amnesia are also disclosed.

Growing community of inventors

Ann Arbor, MI, United States of America

Fred M Hershenson