Senorx, Inc.

Vascular Control Systems, Inc.

Ethicon Endo-surgery, Inc.

Devicor Medical Products, Inc.

Biopsys Medical

Mariposa Biotechnology, Inc.

Sensory Neurostimulation, Inc.

Vascular Control System, Inc.

Hysterx, Inc.

Jones, Michael, L.

Altieri, Greig E.

Burbank, Fred H.

Olson, Ed

Fred H Burbank

Michael L Jones

Paul Lubock

Richard L Quick

Mark Andrew Ritchart

Frank R Louw

Greig E Altieri

J Michael Stuart

Kenneth M Galt

Martin Victor Shabaz

R J Serra

Jill Uyeno

Seth Arnold Foerster

Elias A Zerhouni

Nancy Forcier

Stephen A De Santis

Thomas J Fogarty

John L Wardle

Timothy J Ryan

Wayne E Manska

Jacob Frank Louw

Ed Olson

Elias A Zerbouni

William C Homet

Yu-Tung Wong

Mark F Cole

Stephen DeSantis

Mike Jones

Minh Tran

Al Memmolo

Randy Werneth

Rj Serra

Guillermo Elizondo-Riojas

Michael Jones

Guillermo Av Las Palmas Elizondo-Riojas

A solution for forming a marker or filler mass for an intracorporeal site. The solution contains a polar, water soluble non-aqueous solvent such as dimethyl sulfoxide and a bioabsorbable, essentially water insoluble polymer such as polylactic acid, or copolymers of lactic acid and glycolic acid. The solution may be delivered to the biopsy site by a suitable syringe and delivery tube. The delivery tube is preferably provided with a releasable radiopaque element on the distal tip which can be released within the polymeric marker mass formed in the biopsy cavity.

Marker or filler forming fluid

A system for at least partially filling and marking a cavity within a patient includes a delivery device. A quantity of marker forming fluid is located within the delivery device. The quantity of marker forming fluid is configured to at least partially fill the cavity and form therein a bioabsorbable body after delivery into the cavity from the delivery device. A radiopaque marker, separate from the quantity of marker forming fluid and releasably attached to a portion of the delivery device, is configured to be delivered into the quantity of marker forming fluid in the cavity from the delivery device and configured to remain in the bioabsorbable body upon the formation of the bioabsorbable body in the cavity.

A mass includes particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns. The mass exhibits enhanced detectability by ultrasound energy during the lifetime; the lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward; and a zero or non-zero fluid-to-solid ratio.

Cavity-filling biopsy site markers

An automated system and method of preparing oocytes, embryos, or blastocysts for cryopreservation. The method entails delivering two or more solutions into a container holding oocytes, embryos, or blastocysts, and controlling the flow of the solutions to gradually change the concentration of cryoprotectants and dehydrating agents in the container to minimize shock to the oocytes, embryos or blastocysts.

Method of preparing embryos or blastocysts for cryopreservation

A device and method for treatment of a tissue specimen disposed in surrounding tissue includes isolating the tissue specimen from the surrounding tissue by using a separating device to sever and separate the tissue specimen from the surrounding tissue; damaging the isolated tissue specimen with a tissue specimen damaging device; and using an encapsulating device to encapsulate the isolated and damaged tissue specimen, the encapsulating device configured for operation independent from the separating device and the tissue specimen damaging device.

Tissue specimen isolating and damaging device and method

An automated system and method of cryopreservation of oocytes, embryos, or blastocysts. The method entails delivering two or more solutions into a container holding oocytes, embryos, or blastocysts, and controlling the flow of the solutions to gradually change the concentration of cryoprotectants and dehydrating agents in the container to minimize shock to the oocytes, embryos or blastocysts.

Method of preparing oocytes, embryos, or blastocysts for cryopreservation

A method of marking a biopsy site within a patient's body includes providing a delivery tube having a plunger; carrying a quantity of an ultrasound-detectable bio-resorbable particulate material in the delivery tube distal to the plunger, the ultrasound-detectable bio-resorbable particulate material having a particle size between about 200 microns and about 500 microns and having internal bubble cavities having a size of at least 50 microns; and depressing the plunger for depositing the quantity of the ultrasound-detectable bio-resorbable particulate material at the biopsy site.

A medical device for localization of tissue at a target site in a patient's body includes a tube having a distal end, a proximal end, and a longitudinal axis. The medical device is configured for placement of the distal end at the target site. A fixation device is disposed on the distal end. The affixation device is configured to mechanically fix the distal end of the medical device to tissue at the target site.

Methods and apparatus for securing medical instruments to desired locations in a patient's body

In order to later identify the location of a biopsy or surgery, various means and methods for permanently and non-surgically marking selected tissue in the human body are used. Later visualization of the markers is readily accomplished using state-of-the-art imaging systems.

Methods for defining and marking tissue

An exemplary system for generating a counter-stimulation in a patient suffering from RLS includes a device configured and arranged to generate a counter-stimulation in a patient suffering from RLS, the counter-stimulation of an amplitude, intensity, and time duration lower than that which would wake the patient and higher than that sufficient to relieve RLS, or sufficient to relieve RLS symptoms and allow the patient to return to sleep, a controller configured and arranged to drive the counter-stimulation generation device, the controller being in communication with the counter-stimulation device, and a base configured and arranged to hold the counter-stimulation generation device adjacent to a patient, the counter-stimulation device attached to the base. An exemplary method of treating RLS includes selecting a patient experiencing RLS, and stimulating a portion of the patient at an amplitude, intensity, and duration sufficient to act as a counter-stimulation to RLS.

Devices and methods for treating restless leg syndrome

The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome&#xae; or SenoCor 360&#x2122; cannula.

Cavity filling biopsy site markers

A biopsy system includes a housing, a cannula, a hollow cutter, and a rotatable tissue sample holder. The cannula extends distally from the housing and is rotatable with respect to the housing. The cutter is movable with respect to the cannula for severing tissue received by the cannula. The tissue sample holder includes a plurality of separate tissue sample compartments, the tissue sample compartments being disposed about an axis of rotation of the tissue sample holder. The biopsy system transports severed tissue samples to the tissue sample holder.

Methods and devices for biopsy and collection of soft tissue

A biopsy system includes a cannula, a cutter, and a tissue sample holder. The cannula includes a closed distal end and a lateral tissue receiving port. The cutter is coaxially disposed with the cannula for severing tissue received in the tissue receiving port. The tissue sample holder includes a plurality of discrete tissue sample compartments. The biopsy system transports individual tissue samples to the discrete tissue sample compartments of the tissue sample holder.

An intracorporeal site marker has high ultrasound reflectivity, presents a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The biopsy site marker may include features to fix the marker to the biopsy site so as to resist migration from the biopsy cavity.

Tissue site markers for in vivo imaging

A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.

Growing community of inventors

Laguna Niguel, CA, United States of America

Fred H Burbank