Gen-probe, Inc.

Biomerieux, Inc.

Fred F Hajjar

Michael McClellan Becker

Ali Laayoun

Kenneth A Browne

Lionel Menou

Matthew C Friedenberg

Christelle Tora

Aloke R Banerjee

A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and at least one multivalent metal cation in a substantially aqueous solution; chemically fragmenting the nucleic acid in the mixture to produce a multiplicity of nucleic acid fragments; and attaching at least one label to at least one of the nucleic acid fragments to produce a detectably labeled nucleic acid fragment.

Process for labeling a nucleic acid

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San Diego, CA, United States of America

Fred F Hajjar