Institut Pasteur

Centre National De La Recherche Scientifique

François Clavel

Luc Montagnier

Denise Guetard

Pierre Sonigo

Marc Alizon

Simon Wain-Hobson

Pierre Charneau

Jean-Claude Chermann

Mireille Guyader

Solange Chamaret

Francoise Barre-Sinoussi

Christine Rouzioux

Marianne Rey

Francoise Brun-Vezinet

Bernard Krust

Cole Stewart

Christine Katlama

Olivier Danos

Andrew Borman

Caroline Quillent

Jacqueline Donjon De Saint-Martin

Jacques Cohen

Jacques H M Cohen

Françoise Brun-Vezinet

Françoise Barre-Sinoussi

An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognized by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type (or subtype) O DUR strain.

Nucleotide sequences of HIV-1 group (or subgroup) O retroviral antigens

The invention relates to a composition comprising at least one antigen, wherein the antigen is a protein or glycoprotein of a HIV-2 virus, wherein the HIV-2 virus has infectious properties with respect to human T4 lymphocytes and the essential morphological or immunological property of at least one of the retroviruses deposited at the CNCM under No. I-502, I-532, I-642, and I-643. It also relates to a process for the production of HIV-2 retrovirus antigens by lysing cells infected with the virus or lysing purified virus and recovering the antigens.

HIV-2 antigen compositions

An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type (or subtype) O DUR strain.

Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens

The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399. It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis. It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.

Retrovirus capable of causing AIDS, means and methods for detecting it in vitro

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Paris, France

François Clavel