Sandoz Gmbh

Franz Troxler

Erik Wiskott

Richard Berthold

Paul A Stadler

Fritz Seemann

Gerhard Bormann

This invention provides compounds of ##STR1## wherein R.sub.1 is benzyl or benzyl substituted by hydroxy, chlorine, fluorine, amino, amido, (C.sub.2-5) alkanoylamino, (C.sub.1-4) alkyl, (C.sub.1-4) alkylamino, (C.sub.1-4) alkoxy, (C.sub.1-4) alkylamido, di[(C.sub.1-4) alkyl]amino, or di[(C.sub.1-4) alkyl]amino, R.sub.2, R.sub.4 and R.sub.5 are each (C.sub.1-4) alkyl, and R.sub.3 is (C.sub.2-4) alkyl are prolactin secretion promoters.

Ergot peptide alkaloid derivatives, processes for their preparation and

This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is phenyl; phenyl monosubstituted with fluorine; phenyl mono- or disubstituted with chlorine; phenyl mono-, di- or trisubstituted with methyl or methoxy, secondary 1-phenoxyalkyl, the secondary alkyl residue of which is of 3 to 5 carbon atoms and in which the phenyl residue is unsubstituted or monosubstituted with chlorine, and

Use of 4-(2-benzoyloxy-3-tert-butylaminopropoxy)-2-methyl-indole for

The invention provides indole compounds useful for the treatment of hypertension, processes for the preparation of said compounds and pharmaceutical compositions containing these compounds. The compounds of the invention have the formula ##STR1## wherein n is 2 or 3, A is 1,4-cyclohexylidene or trimethylene and R.sub.1 is H or alkyl, or A together with NR.sub.1 is 4-piperidyl, R.sub.2 is hydrogen or alkyl, R.sub.3 is alkyl, cycloalkyl, amino, alkylamino, dialkylamino, phenylamino, unsubstituted or substituted phenyl or benzyl, pyridylmethyl or an heterocycle, R.sub.4 is hydrogen, chlorine, bromine or alkyl, R.sub.5 is hydrogen, alkyl, alkoxy or alkylthio, and X is --CO-- or --CS.

N-Benzoyl-N'-3-indolyl-N'alkyl-1,3-diaminopropanes

4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole

This invention provides compounds of formula I ##STR1## wherein R.sub.1 is

Thieno[3,2-c]pyridines

This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, and

3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

The invention provides new (3aRS,4SR,7aRS)-4-phenyl-hexahydro-4-indolinol derivatives useful as anti-depressants and anti-arrhythmics.

-4-Phenylhexahydro-4-indolinol derivatives

This invention provides compounds of formula I, ##STR1## wherein R.sub.1 is alkyl, alkenyl or alkinyl of up to 9 carbon atoms, or 1-ethinylcycloalkyl,

2-Substituted-aminopropoxy indoles

This invention provides new compounds of formula I, ##STR1## wherein R is lower alkyl or cycloalkyl of 3 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms substituted by alkyl of 1 to 4 carbon atoms; .alpha.-dialkylpropinyl or .alpha.-dialkylallyl of 5 to 9 carbon atoms; hydroxyalkyl of 2 to 7 carbon atoms, the hydroxy group thereof being separated by at least two carbon atoms from the nitrogen atom to which R is bound; phenethyl; phenethyl substituted by halogen, alkyl or alkoxy of 1 to 4 carbon atoms; or adamantyl,

Isoquinoline compounds

This invention provides new compounds of formula I, ##STR1## wherein R is alkyl of 3 to 7 carbon atoms or cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubstituted by alkyl of 1 to 4 carbon atoms, .alpha.-dialkylpropynyl of 5 to 9 carbon atoms or .alpha.-dialkyl-allyl of 5 to 9 carbon atoms, hydroxyalkyl of 2 to 7 carbon atoms or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the last two radicals being separated by at least two carbon atoms from the nitrogen atom to which R is bound,

1-Substituted-amino-3-(4-furo[3,2-c]pyridinyloxy)-2-propanols

This invention provides compounds of formula I, ##STR1## wherein R is alkyl of 3 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms monosubstituted with alkyl of 1 to 4 carbon atoms; .alpha.-dialkylpropinyl of 5 to 9 carbon atoms; .alpha.-dialkylallyl of 5 to 9 carbon atoms; hydroxyalkyl of 2 to 7 carbon atoms, the hydroxy group thereof being separated by at least two carbon atoms from the nitrogen atom to which R is bound; phenethyl; phenethyl mono- or disubstituted in the phenyl residue independently when di-substituted with halogen of atomic number from 9 to 35, alkyl of 1 to 4 carbon atoms or unbranched alkoxy of 1 to 4 carbon atoms; or adamantyl; and

Certain 1-amino-3-(1-isoquinolinyl)oxy-2-propanol derivatives

The present invention concerns novel compounds of formula I, ##STR1## wherein R.sub.1 is hydroxy, or ##STR2## wherein N IS AN INTEGER FROM 1 TO 5, AND

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Bottmingen, Switzerland

Franz Troxler