Bayer Aktiengesellschaft

Franz-Peter Hoever

Elisabeth Perzborn

Ulrich Niewohner

Volker-Bernd Fiedler

Friedel Seuter

Bernd-Wieland Kruger

Klaus Sasse

Gunther Nentwig

Wolfgang Behrenz

Folker Lieb

Ulrich Rosentreter

Rolf Grosser

Walter Lange

Michael Grosse-Bley

Dieter Arlt

Bodo Junge

Bruno Bomer

Hilary P Francis

Marie G McKenniff

Horst Boshagen

Hermann Oediger

Peter Norman

Bruno B&ouml;mer

Peter Norma

Wolfgang Berhrenz

The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.

Polymers chromatographic separation of enantiomers

The invention relates to new optically active amino acid derivatives of the general formula (I) ##STR1## in which n, R, R.sub.1, R.sub.2, R.sub.3, X and A have the meaning given in the description, which amino acid derivatives contain sulphoxide or sulphone groups, to two basic synthetic routes for the preparation from sulphur-containing amino acids, to the polymerization of these monomers and to the use of the polymers as optically active adsorbents for chromatographic resolution of racemates to give the enantiomers.

Optically active amino acid sulphoxide and amino acid sulphone

Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.

Antithrombotic iso- and heterocyclic phenylsulphonamides

It has been found that the substituted .alpha.,.omega.-amino-alcohol derivatives, some of which are known, of the formula I ##STR1## in which X represents hydrogen, COR.sup.11, COOR.sup.12 or R.sup.13,

Agents for repelling insects and mites

Repelling insects and mites with acylated .alpha.,.omega., aminoalcohol derivatives of the formula ##STR1## in which X represents hydrogen, COR.sup.11, COOR.sup.12 or R.sup.13,

Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substrituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, and

Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes

Substituted .alpha.,.omega.-aminoalcohol derivatives

Certain intermediate aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivatives of the formula ##STR1## in which R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, and

Intermediates for circulation-active substituted

For inhibiting thombocyte aggregation, vasodilating and bronchodilating, the new chroman derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, alkyl, hydroxyl, alkoxy, trifluoromethyl or cyano,

Chroman derivatives for combating thrombosis and asthma

Repelling insects and mites with acylated .alpha.,.omega.-aminoalcohol derivatives of the formula ##STR1## in which X represents hydrogen, COR.sup.11, COOR.sup.12 or R.sup.13,

Acylated aminoalcohols for repelling insects and mites

An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,

Circulation-active novel substituted

Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, and

Growing community of inventors

Cologne, Germany

Franz-Peter Hoever