Schering Aktiengesellschaft

Franz-Josef Renneke

Heinz Gries

Hanns-Joachim Weinmann

Ulrich Speck

Douwe Rosenberg

Georg-Alexander Hoyer

Wolfgang Mutzel

Heinrich Pfeiffer, Deceased

Ulrich Niedballa

Erich Klieger

Julius Deutsch

Wolfgang Muetzel

Heribert Schmitt-Willich

Jurgen Conrad

Heinrich Pfeiffer

Juergen Conrad

Wolfgang M Utzel

1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4,

Substituted complexing agents, complexes, and complex salts, processes

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic number of 21 to 29, 42, 44 or 57 to 83 and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.

Sterile composition comprising a chelate complex for magnetic resonance

Diagnostic media

Method of enhancing paramagnetism in chelates for MRI

Substituted polyamino, polycarboxy complexing agent dimers for MRI and

Compounds of the general formula I: ##STR1## wherein R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## and X represents hydrogen atoms and/or metal ion equivalents, and their salts with physiologically harmless organic bases, are valuable complexing agents, complexes and complex salts for diagnostic imaging.

Complexing agents, complexes and complex salts

A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more Gadolinium ions and, optionally, one or more physiologically biocompatible cation or cations of an inorganic and/or organic base or amino acid, optionally, with additives customary in galenic formulations, dissolved or suspended in an aqueous medium.

Gadolinium chelates for magnetic resonance imaging

Compounds of the general formula I: ##STR1## R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## wherein j signifies the numbers 1 to 4 and R.sup.x signifies a hydrogen atom, a lower alkoxy group with 1 to 4 carbon atoms, a COOX group, or if j&gt;1, also the group ##STR5## wherein k and m are the same or different and represent the numbers 0 or 2, l signifies the numbers 1 or 2 and n and w are the same or different and signify the numbers 0 or 1,

NMR imaging using paramagnetic chelates having hydroxyalkyl-substituted

Growing community of inventors

Berlin, Germany

Franz-Josef Renneke