Hoechst Aktiengesellschaft

Franz Hock

Hansjorg Urbach

Rainer Henning

Wolfgang Ruger

Wolf-Ulrich Nickel

Ulrich Lerch

Reinhard Becker

Josef Scholtholt

Jens Stechl

Jochen Knolle

Bernward Scholkens

Gerhard Breipohl

Joachim Kaiser

Hans-Wolfram Fehlhaber

Stephan Henke

Hermann J Gerhards

Hiristo Anagnostopulos

Elmar Konz

Hansjorg Kruse

Gabriele Wiemer

Patricia Usinger

Hansjorj Urbach

Peptides having bradykinin antagonist action

The invention relates to new comoounds having a cognition adjuvant action, to the use of ACE inhibitors as medicaments having a cognition adjuvant action, to agents containing them, and to the use thereof for the treatment and prophylaxis of cognitive dysfunctions.

Compounds having a cognition adjuvant action, agents containing them,

New amino acid esters, a process for their preparation, medicaments containing them, and the use thereof The invention relates to amino acid esters of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 denote hydrogen or a defined radical, R.sup.4 together with R.sup.5 and the atoms carrying them form a heterocyclic ring system, to a process for their preparation, to agents containing them, and to the use thereof.

New amino acid esters, a process for their preparation, medicaments

The invention relates to compounds of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R.sup.2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring .alpha.-amino acid, R.sup.4 can additionally represent ##STR2## R.sup.3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R.sup.3 and R.sup.4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system,

Piperazinediones having a psychotropic action

The present invention relates to compounds of the formula I ##STR1## in which R.sup.1 to R.sup.4 are defined in the description, processes for their preparation, their use for the treatment and prophylaxis of cognitive dysfunctions and pharmaceuticals containing them and processes for their preparation.

Pyrrolidine-2-carboxylic acid derivatives and their use for psychotropic

The invention relates to amino acid esters of the formula ##STR1## in which n=1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 denote hydrogen or a defined radical, R.sup.4 together with R.sup.5 and the atoms carrying them form a heterocyclic ring system, processes for their preparation, agents containing them and their use.

Novel amino acid glycerides, learning medicaments containing them and

The invention relates to amino acid esters of the formula I ##STR1## in which n is 2 and R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning indicated in the description, to a process and intermediates for the preparation thereof, to agents containing them, and the use thereof.

Amino acid esters, pharmaceuticals containing them, and the use thereof

Compounds with a psychotropic action, agents containing them, and the use thereof for the treatment and prophylaxis of disorders of the central nervous system. The invention relates to the use of angiotensin converting enzyme inhibitors as pharmaceuticals with a psychotropic, especially anxiolytic, action, to agents containing them, and to the use thereof for the treatment or prophylaxis of disorders of the central nervous system, especially of anxiety states. The invention also relates to new compounds of the formula ##STR1## in which R.sup.2 denotes hydrogen or ethyl, and R.sup.3 denotes n-octyl, to processes for the preparation thereof, to agents containing them, and to the use thereof as pharmaceuticals.

Compounds with a psychotropic action, agents containing them, and the

The invention relates to derivatives of cyclic amino acids of the general formula ##STR1## in which R.sup.1 denotes hydrogen, alkyl, alkenyl or (subst.) aryl,

Derivatives of cyclic amino acids, agents containing them, and the use

The invention rleates to pyrrolidine derivatives of the general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meaning indicated in the description; X denotes oxygen, imino or N-alkylimino; m is 0-5; n is 0-2 and s is 0 or 1; a process for their preparation, agents containing them, and their use.

New 2-acylpyrrolidine derivatives, a process for the preparation

Novel pyrrolidine-2-(1,3-dicarbonyl) derivatives, a process for their preparation, agents containing them, and their use The invention relates to pyrrolidine derivatives of the general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meaning specified in the description, X denotes oxygen, imino or alkylimino,

Novel pyrrolidine-2-(1,3-dicarbonyl) derivatives, a process for their

New isoquinoline derivatives of the general formula ##STR1## and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.

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Dieburg, Germany

Franz Hock