Technische Universitat Graz

Vtu Holding Gmbh

Franz Hartner

Anton Glieder

A mutantalcohol oxidase 1 (AOX1) promoter of the wild typeAOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (&#x2212;784 to &#x2212;719), nucleotides 170 to 191 (&#x2212;784 to &#x2212;763), nucleotides 192 to 213 (&#x2212;762 to &#x2212;741), nucleotides 192 to 210 (&#x2212;762 to &#x2212;744), nucleotides 207 to 209 (&#x2212;747 to &#x2212;745), nucleotides 214 to 235 (&#x2212;740 to &#x2212;719), nucleotides 304 to 350 (&#x2212;650 to &#x2212;604), nucleotides 364 to 393 (&#x2212;590 to &#x2212;561), nucleotides 434 to 508 (&#x2212;520 to &#x2212;446), nucleotides 509 to 551 (&#x2212;445 to &#x2212;403), nucleotides 552 to 560 (&#x2212;402 to &#x2212;394), nucleotides 585 to 617 (&#x2212;369 to &#x2212;337), nucleotides 621 to 660 (&#x2212;333 to &#x2212;294), nucleotides 625 to 683 (&#x2212;329 to &#x2212;271), nucleotides 736 to 741 (&#x2212;218 to &#x2212;213), nucleotides 737 to 738 (&#x2212;217 to &#x2212;216), nucleotides 726 to 755 (&#x2212;228 to &#x2212;199), nucleotides 784 to 800 (&#x2212;170 to &#x2212;154) or nucleotides 823 to 861 (&#x2212;131 to &#x2212;93) of Seq ID No. 1, and combinations thereof.

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Graz, Austria

Franz Hartner