Fresenius Ag

Franz Cech

Klaus Sommermeyer

Klaus Henning

Reinhold Herbert

Burghard Weidler

Jurgen Koenig

A hydroxyethyl starch for use as plasma expander which is obtainable by hydrolytic predegradation of a starch rich in amylopectin, partial hydroxyethylation to a specific substitution degree in the presence of alkali and subsequent hydrolytic degradation to a specific molecular weight, comprises a mean molecular weight of 60,000-600,000 and a substitution degree MS of 0.15-0.5. The ratio of the substitution of C2 to the substitution of C6 of the anhydroglucose units is 8-20 and the substitution degree DS lies in the range from 0.15 to 0.5. A process for the preparation of this hydroxyethyl starch employs 2-chloroethanol as hydroxyethylation agent. The hydroxyethylation is carried out under alkaline conditions at room temperature, the pH value held at a value of about 12 and the temperature held at a value of about 20.degree. C.

Hydroxylethylstarch (HES) as plasma expander and process for preparing

The present invention describes package units for medical purposes, in particular for receiving and/or storing sterilizable preparations for parenteral uses or dialysis solutions, comprising a container having at least one discharge spout and consisting of polyamide 66 or a laminate of polyamide 66 sheet and polyolefin sheet, the polyolefin sheet being disposed on the side facing the liquid to be stored and the sheet of polyamide 66 being disposed on the outside and the two sheets being bonded together in usual manner by means of an adhesive. The package units may further comprise an inner container or an outer container. The package unit is made in that a container having at least one discharge spout is made from polyamide 66 or the aforementioned laminate, said container filled with the liquid to be stored, then sealed and sterilized and possibly subsequently surrounded after cooling and drying with an outer container of polymeric material. Package units according to the invention may also be made in that from a polymeric material an inner container having at least one discharge spout is made, said container filled with the liquid to be stored, sealed, then surrounded with an outer container of polyamide 66 or a laminate of polyamide 66 sheet and polyolefin sheet, the polyolefin sheet being disposed at the side of the laminate facing the inner container and the sheet of polyamide 66 of the laminate representing the outer sheet, and thereafter sterilized.

Growing community of inventors

Rosbach, Germany

Franz Cech